Cancer risk among participants in the women's interagency HIV study

Nancy A. Hessol, Eric Carl Seaberg, Susan Preston-Martin, L. Stewart Massad, Henry S. Sacks, Sylvia Silver, Sandra Melnick, Ovadia Abulafia, Alexandra M. Levine

Research output: Contribution to journalArticle

Abstract

Background: The HIV epidemic has been associated with an increased incidence of specific cancers. However, less is known about cancers occurring in HIV-infected women than men. Methods: To determine the risk of cancer among HIV-infected and at-risk HIV-uninfected women, cancer incidence data from the Women's Interagency HIV Study (WIHS) were compared with data from the population-based United States Surveillance, Epidemiology, and End Results (SEER) registry. Age- and race-adjusted standardized incidence ratios (SIRs) were computed and exact statistical tests were used to measure significance. Results: Among the 1950 women participants (1554 HIV infected, 391 HIV uninfected, and 5 HIV seroconverters), 48 cancers were diagnosed during study follow-up. Among HIV-infected women, significantly (P <0.05) increased incidence rates were observed for all cancer types (SIR = 1.9), Kaposi sarcoma (SIR = 213.5), non-Hodgkin lymphoma (NHL) (SIR = 19.0), and lung cancer (SIR = 6.3) when compared with SEER rates. Lung cancer incidence was also elevated (P = 0.07) among the HIV-uninfected women (SIR = 6.9), when compared with SEER rates, and was similar to the SIR for HIV-infected women. While the incidence rate of NHL among HIV-infected women was significantly lower during the era of highly active antiretroviral therapy (HAART) compared with the pre-HAART era (relative risk = 0.15, P = 0.005), the incidence of NHL among HIV-infected WIHS participants remained significantly higher than in the US population (SIR = 6.4, 95% CI = 1.3-15.5). Conclusion: In the HAART era, the higher rates of cancer among HIV-infected women, coupled with increased life expectancy, should lead to more intensive cancer screening and prevention efforts in this population.

Original languageEnglish (US)
Pages (from-to)978-985
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume36
Issue number4
DOIs
StatePublished - Aug 1 2004

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HIV
Incidence
Neoplasms
Highly Active Antiretroviral Therapy
Non-Hodgkin's Lymphoma
Epidemiology
Lung Neoplasms
Population
Kaposi's Sarcoma
Life Expectancy
Early Detection of Cancer
Registries

Keywords

  • AIDS
  • Cancer
  • HIV infection
  • Malignancy
  • Standardized incidence ratio

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Hessol, N. A., Seaberg, E. C., Preston-Martin, S., Massad, L. S., Sacks, H. S., Silver, S., ... Levine, A. M. (2004). Cancer risk among participants in the women's interagency HIV study. Journal of Acquired Immune Deficiency Syndromes, 36(4), 978-985. https://doi.org/10.1097/00126334-200408010-00013

Cancer risk among participants in the women's interagency HIV study. / Hessol, Nancy A.; Seaberg, Eric Carl; Preston-Martin, Susan; Massad, L. Stewart; Sacks, Henry S.; Silver, Sylvia; Melnick, Sandra; Abulafia, Ovadia; Levine, Alexandra M.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 36, No. 4, 01.08.2004, p. 978-985.

Research output: Contribution to journalArticle

Hessol, NA, Seaberg, EC, Preston-Martin, S, Massad, LS, Sacks, HS, Silver, S, Melnick, S, Abulafia, O & Levine, AM 2004, 'Cancer risk among participants in the women's interagency HIV study', Journal of Acquired Immune Deficiency Syndromes, vol. 36, no. 4, pp. 978-985. https://doi.org/10.1097/00126334-200408010-00013
Hessol, Nancy A. ; Seaberg, Eric Carl ; Preston-Martin, Susan ; Massad, L. Stewart ; Sacks, Henry S. ; Silver, Sylvia ; Melnick, Sandra ; Abulafia, Ovadia ; Levine, Alexandra M. / Cancer risk among participants in the women's interagency HIV study. In: Journal of Acquired Immune Deficiency Syndromes. 2004 ; Vol. 36, No. 4. pp. 978-985.
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AU - Sacks, Henry S.

AU - Silver, Sylvia

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