Cancer risk after abo-incompatible living-donor kidney transplantation

Erin C. Hall, Eric A. Engels, Robert A. Montgomery, Dorry L. Segev

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Recipients of ABO-incompatible (ABOi) living-donor kidney transplants often undergo more intense immunosuppression than their ABO-compatible counterparts. It is unknown if this difference leads to higher cancer risk after transplantation. Single-center studies are too small and lack adequate duration of follow-up to answer this question. METHODS: We identified 318 ABOi recipients in the Transplant Cancer Match Study, a national linkage between the Scientific Registry of Transplant Recipients and population-based U.S. cancer registries. Seven cancers (non-Hodgkin lymphoma, Merkel cell carcinoma, gastric adenocarcinoma, hepatocellular carcinoma, thyroid cancer, pancreatic cancer, and testicular cancer) were identified among ABOi recipients. We then matched ABOi recipients to ABO-compatible controls by age, gender, race, human leukocyte antigen mismatch, retransplantation, and transplant year. RESULTS: There was no demonstrable association between ABOi and cancer in unadjusted (incidence rate ratio, 0.83; 95% confidence interval, 0.33-1.71; P=0.3) or matched control (incidence rate ratio, 0.99; 95% confidence interval, 0.38-2.23; P=0.5) analyses. CONCLUSION: To the extent that could be determined in this registry study, current desensitization protocols are not associated with increased risk of cancer after transplantation.

Original languageEnglish (US)
Pages (from-to)476-479
Number of pages4
JournalTransplantation
Volume96
Issue number5
DOIs
StatePublished - Jun 28 2013

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Keywords

  • Cancer
  • Incompatible transplantation
  • Living-donor kidney transplantation

ASJC Scopus subject areas

  • Transplantation

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