Cancer Incidence by Levels of Cholesterol

Roger R. Williams, Paul D. Sorlie, Manning Feinleib, Patricia M. McNamara, William B. Kannel, Thomas R. Dawber

Research output: Contribution to journalArticle

Abstract

In 5,209 subjects studied for 24 years in Framingham, Mass, 691 cases of cancer were documented, with histological confirmation for 94%. Predetermined personal characteristics were tested for associations with subsequent occurrence of cancer at specific sites using multiple logistic regression. Significant associations of various cancer sites with cigarette smoking, alcohol use, education, height, weight, and parity agreed with other studies. Serum cholesterol level was inversely associated with incidence of colon cancer and with other sites only in men; these inverse associations were statistically significant after adjustment for age, alcohol consumption, cigarette smoking, education, systolic blood pressure, and relative weight. Associations may reflect effects of competing lethal diseases, underlying pathophysiological mechanisms that promote or inhibit development of cancer in men, biologic or social response to early and undiagnosed states of cancer. (JAMA 1981;245:247-252).

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalJournal of the American Medical Association
Volume245
Issue number3
DOIs
StatePublished - Jan 16 1981
Externally publishedYes

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Cholesterol
Incidence
Neoplasms
Smoking
Blood Pressure
Education
Weights and Measures
Parity
Alcohol Drinking
Colonic Neoplasms
Logistic Models
Alcohols
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Williams, R. R., Sorlie, P. D., Feinleib, M., McNamara, P. M., Kannel, W. B., & Dawber, T. R. (1981). Cancer Incidence by Levels of Cholesterol. Journal of the American Medical Association, 245(3), 247-252. https://doi.org/10.1001/jama.1981.03310280023021

Cancer Incidence by Levels of Cholesterol. / Williams, Roger R.; Sorlie, Paul D.; Feinleib, Manning; McNamara, Patricia M.; Kannel, William B.; Dawber, Thomas R.

In: Journal of the American Medical Association, Vol. 245, No. 3, 16.01.1981, p. 247-252.

Research output: Contribution to journalArticle

Williams, RR, Sorlie, PD, Feinleib, M, McNamara, PM, Kannel, WB & Dawber, TR 1981, 'Cancer Incidence by Levels of Cholesterol', Journal of the American Medical Association, vol. 245, no. 3, pp. 247-252. https://doi.org/10.1001/jama.1981.03310280023021
Williams RR, Sorlie PD, Feinleib M, McNamara PM, Kannel WB, Dawber TR. Cancer Incidence by Levels of Cholesterol. Journal of the American Medical Association. 1981 Jan 16;245(3):247-252. https://doi.org/10.1001/jama.1981.03310280023021
Williams, Roger R. ; Sorlie, Paul D. ; Feinleib, Manning ; McNamara, Patricia M. ; Kannel, William B. ; Dawber, Thomas R. / Cancer Incidence by Levels of Cholesterol. In: Journal of the American Medical Association. 1981 ; Vol. 245, No. 3. pp. 247-252.
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