Cancer epigenetics is no Mickey Mouse

Andrew P. Feinberg

doi:10.1016/j.ccr.2005.09.014

Cancer epigenetics is no Mickey Mouse

Andrew P. Feinberg

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

36 Scopus citations

Abstract

Epigenetic changes are the most common alterations in human cancer, but it has been difficult to sort out cause and effect from studies of human tumors. Several recent nonlethal mouse models implicate both hypomethylation and loss of imprinting (LOI) in tumor formation, including a paper in this issue of Cancer Cell showing that transient hypomethylation in ES cells causes LOI and liver and intestinal tumors (Holm et al., 2005). Hypomethylation appears to be a critical determinant of cancer, affecting chromosomal stability and specific gene targets.

Original language	English (US)
Pages (from-to)	267-268
Number of pages	2
Journal	Cancer cell
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/j.ccr.2005.09.014
State	Published - Oct 2005

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1016/j.ccr.2005.09.014

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AB - Epigenetic changes are the most common alterations in human cancer, but it has been difficult to sort out cause and effect from studies of human tumors. Several recent nonlethal mouse models implicate both hypomethylation and loss of imprinting (LOI) in tumor formation, including a paper in this issue of Cancer Cell showing that transient hypomethylation in ES cells causes LOI and liver and intestinal tumors (Holm et al., 2005). Hypomethylation appears to be a critical determinant of cancer, affecting chromosomal stability and specific gene targets.

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Cancer epigenetics is no Mickey Mouse

Abstract

ASJC Scopus subject areas

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