Cancer diagnosis, risk assessment and prediction of therapeutic response by means of DNA methylation markers

Heidi Fiegl, Karim Elmasry

Research output: Contribution to journalReview articlepeer-review

Abstract

Epigenetic alterations are heritable changes in gene expression without an accompanying change in primary DNA sequence. Two major mechanisms that cause epigenetic changes are post-translational histone modifications and DNA methylation at cytosine bases within a CpG dinucleotide. Epigenetic defects have turned out to be one of the most common molecular alterations in human neoplasia. Promoter hypermethylation is associated with loss of expression of tumour suppressor genes in cancer. The analysis of aberrant DNA methylation is gaining strength in the fields of cancer risk assessment, diagnosis, and therapy monitoring in different cancer types. These issues are discussed in this review.

Original languageEnglish (US)
Pages (from-to)89-96
Number of pages8
JournalDisease Markers
Volume23
Issue number1-2
DOIs
StatePublished - 2007

Keywords

  • Cancer risk assessment
  • Diagnostics
  • Methylation
  • Prediction

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

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