TY - JOUR
T1 - Cancer cell motility
T2 - Lessons from migration in confined spaces
AU - Paul, Colin D.
AU - Mistriotis, Panagiotis
AU - Konstantopoulos, Konstantinos
N1 - Publisher Copyright:
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
PY - 2017/1/27
Y1 - 2017/1/27
N2 - Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features of tissues or be created by tumour or tumour-associated cells. Importantly, migration mechanisms through confining microenvironments are not predicted by 2D migration assays. Engineered in vitro models have been used to delineate the mechanisms of cell motility through confining spaces encountered in vivo. Understanding cancer cell locomotion through physiologically relevant confining tracks could be useful in developing therapeutic strategies to combat metastasis.
AB - Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features of tissues or be created by tumour or tumour-associated cells. Importantly, migration mechanisms through confining microenvironments are not predicted by 2D migration assays. Engineered in vitro models have been used to delineate the mechanisms of cell motility through confining spaces encountered in vivo. Understanding cancer cell locomotion through physiologically relevant confining tracks could be useful in developing therapeutic strategies to combat metastasis.
UR - http://www.scopus.com/inward/record.url?scp=85001022254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85001022254&partnerID=8YFLogxK
U2 - 10.1038/nrc.2016.123
DO - 10.1038/nrc.2016.123
M3 - Review article
C2 - 27909339
AN - SCOPUS:85001022254
SN - 1474-175X
VL - 17
SP - 131
EP - 140
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 2
ER -