Cancer cell motility: Lessons from migration in confined spaces

Colin D. Paul, Panagiotis Mistriotis, Konstantinos Konstantopoulos

Research output: Contribution to journalReview articlepeer-review

Abstract

Time-lapse, deep-tissue imaging made possible by advances in intravital microscopy has demonstrated the importance of tumour cell migration through confining tracks in vivo. These tracks may either be endogenous features of tissues or be created by tumour or tumour-associated cells. Importantly, migration mechanisms through confining microenvironments are not predicted by 2D migration assays. Engineered in vitro models have been used to delineate the mechanisms of cell motility through confining spaces encountered in vivo. Understanding cancer cell locomotion through physiologically relevant confining tracks could be useful in developing therapeutic strategies to combat metastasis.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
JournalNature Reviews Cancer
Volume17
Issue number2
DOIs
StatePublished - Jan 27 2017

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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