Cancer cell metabolism: There is no ROS for the weary

Chi V. Dang

Research output: Contribution to journalArticle


Using a high-throughput short-hairpin RNA library screen targeting 222 metabolic nodes, Ros and colleagues identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), a glycolytic enzyme that shunts glucose into the pentose phosphate pathway for NADPH production, as a critical node for the survival of prostate cancer cells. Blocking PFKFB4 induces reactive oxygen species and cancer cell death, suggesting that PFKFB4 could be therapeutically targeted.

Original languageEnglish (US)
Pages (from-to)304-307
Number of pages4
JournalCancer Discovery
Issue number4
StatePublished - Apr 2012
Externally publishedYes

ASJC Scopus subject areas

  • Oncology

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