Abstract
Using a high-throughput short-hairpin RNA library screen targeting 222 metabolic nodes, Ros and colleagues identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), a glycolytic enzyme that shunts glucose into the pentose phosphate pathway for NADPH production, as a critical node for the survival of prostate cancer cells. Blocking PFKFB4 induces reactive oxygen species and cancer cell death, suggesting that PFKFB4 could be therapeutically targeted.
Original language | English (US) |
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Pages (from-to) | 304-307 |
Number of pages | 4 |
Journal | Cancer Discovery |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2012 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology