Cancer cell metabolism: There is no ROS for the weary

Chi V. Dang

Research output: Contribution to journalArticle

Abstract

Using a high-throughput short-hairpin RNA library screen targeting 222 metabolic nodes, Ros and colleagues identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4), a glycolytic enzyme that shunts glucose into the pentose phosphate pathway for NADPH production, as a critical node for the survival of prostate cancer cells. Blocking PFKFB4 induces reactive oxygen species and cancer cell death, suggesting that PFKFB4 could be therapeutically targeted.

Original languageEnglish (US)
Pages (from-to)304-307
Number of pages4
JournalCancer Discovery
Volume2
Issue number4
DOIs
StatePublished - Apr 2012
Externally publishedYes

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Fructose
Phosphotransferases
Phosphofructokinase-2
Pentose Phosphate Pathway
Neoplasms
NADP
Small Interfering RNA
Reactive Oxygen Species
Prostatic Neoplasms
Cell Death
Glucose
Enzymes

ASJC Scopus subject areas

  • Oncology

Cite this

Cancer cell metabolism : There is no ROS for the weary. / Dang, Chi V.

In: Cancer Discovery, Vol. 2, No. 4, 04.2012, p. 304-307.

Research output: Contribution to journalArticle

Dang, Chi V. / Cancer cell metabolism : There is no ROS for the weary. In: Cancer Discovery. 2012 ; Vol. 2, No. 4. pp. 304-307.
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