Cancer cachexia, recent advances, and future directions

Research output: Contribution to journalReview article

Abstract

Cancer cachexia is defined as a multifactorial syndrome characterized by an ongoing loss of skeletal muscle masswith or without loss of fat mass. The syndrome cannot be fully reversed by conventional nutritional support, and despite an increased number of studies related to cancer cachexia, the underlying mechanisms are still poorly defined, and therapeutic options are limited. This review focuses on recent studies investigating mechanisms and pathways in cancer cachexia. The role of molecular and functional imaging in identifying cachexia at an earlier stage, in identifying potentialmetabolic targets and pathways, and in assessing treatment efficacy is also reviewed.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalCancer Journal (United States)
Volume21
Issue number2
DOIs
StatePublished - Mar 9 2015

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Keywords

  • Cancer cachexia
  • molecular mechanisms
  • noninvasive imaging
  • treatment options

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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