Cancer-associated alteration in fatty acid binding to albumin studied by spin-label electron spin resonance

Andrey Gurachevsky; Ekaterina Muravskaya; Tatjana Gurachevskaya; Lena Smirnova; Vladimir Muravsky

doi:10.1080/07357900701407947

Cancer-associated alteration in fatty acid binding to albumin studied by spin-label electron spin resonance

Andrey Gurachevsky, Ekaterina Muravskaya, Tatjana Gurachevskaya, Lena Smirnova, Vladimir Muravsky

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Human serum albumin accumulates low molecular weight biomarkers related to cancer. This accumulation can lead to allosteric modification of albumin and change its ability to bind essential fatty acids. Using 16-doxyl-stearic acid spin probe, which is specific for albumin, the serum samples of 98 patients with a variety of cancer types and 86 cancer free individuals were analysed by electron spin resonance (ESR) spectroscopy in order to evaluate cancer-induced modifications that occur to albumin. The ESR spectra showed significant differences between the investigated groups. These differences were most apparent in the intensities and widths of the spectral lines corresponding to the different types of albumin binding sites.

Original language	English (US)
Pages (from-to)	378-383
Number of pages	6
Journal	Cancer Investigation
Volume	25
Issue number	6
DOIs	https://doi.org/10.1080/07357900701407947
State	Published - Sep 2007
Externally published	Yes

Keywords

Cancer
Electron spin resonance
Fatty acid
Neural networks
Serum albumin
Spin probe

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1080/07357900701407947

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title = "Cancer-associated alteration in fatty acid binding to albumin studied by spin-label electron spin resonance",

abstract = "Human serum albumin accumulates low molecular weight biomarkers related to cancer. This accumulation can lead to allosteric modification of albumin and change its ability to bind essential fatty acids. Using 16-doxyl-stearic acid spin probe, which is specific for albumin, the serum samples of 98 patients with a variety of cancer types and 86 cancer free individuals were analysed by electron spin resonance (ESR) spectroscopy in order to evaluate cancer-induced modifications that occur to albumin. The ESR spectra showed significant differences between the investigated groups. These differences were most apparent in the intensities and widths of the spectral lines corresponding to the different types of albumin binding sites.",

keywords = "Cancer, Electron spin resonance, Fatty acid, Neural networks, Serum albumin, Spin probe",

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T1 - Cancer-associated alteration in fatty acid binding to albumin studied by spin-label electron spin resonance

AU - Gurachevsky, Andrey

AU - Muravskaya, Ekaterina

AU - Gurachevskaya, Tatjana

AU - Smirnova, Lena

AU - Muravsky, Vladimir

PY - 2007/9

Y1 - 2007/9

N2 - Human serum albumin accumulates low molecular weight biomarkers related to cancer. This accumulation can lead to allosteric modification of albumin and change its ability to bind essential fatty acids. Using 16-doxyl-stearic acid spin probe, which is specific for albumin, the serum samples of 98 patients with a variety of cancer types and 86 cancer free individuals were analysed by electron spin resonance (ESR) spectroscopy in order to evaluate cancer-induced modifications that occur to albumin. The ESR spectra showed significant differences between the investigated groups. These differences were most apparent in the intensities and widths of the spectral lines corresponding to the different types of albumin binding sites.

AB - Human serum albumin accumulates low molecular weight biomarkers related to cancer. This accumulation can lead to allosteric modification of albumin and change its ability to bind essential fatty acids. Using 16-doxyl-stearic acid spin probe, which is specific for albumin, the serum samples of 98 patients with a variety of cancer types and 86 cancer free individuals were analysed by electron spin resonance (ESR) spectroscopy in order to evaluate cancer-induced modifications that occur to albumin. The ESR spectra showed significant differences between the investigated groups. These differences were most apparent in the intensities and widths of the spectral lines corresponding to the different types of albumin binding sites.

KW - Cancer

KW - Electron spin resonance

KW - Fatty acid

KW - Neural networks

KW - Serum albumin

KW - Spin probe

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JO - Cancer Investigation

JF - Cancer Investigation

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ER -

Cancer-associated alteration in fatty acid binding to albumin studied by spin-label electron spin resonance

Abstract

Keywords

ASJC Scopus subject areas

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