TY - JOUR
T1 - Cancer as a social dysfunction—why cancer research needs new thinking
AU - Axelrod, Robert
AU - Pienta, Kenneth J.
N1 - Publisher Copyright:
© 2018 American Association for Cancer Research.
PY - 2018/9
Y1 - 2018/9
N2 - The incidence and mortality for many cancers continue to rise. As such, critical action is needed on many fronts to reshape how a society thinks, discusses, and fights cancer especially as the population grows and ages. Cancer can be described as a broken social contract that requires different conceptual frameworks such as game theory. To this end, it is our hope that this perspective will catalyze a discussion to rethink the way we approach, communicate, and fund cancer research; thinking of cancer as a broken social contract is only one example. Importantly, this endeavor will require infusion of ideas from other fields such as physics, computational medicine, complexity science, agent-based modeling, sociology, and ecology, all of which have the capacity to drive new insights into cancer biology and clinical medicine.
AB - The incidence and mortality for many cancers continue to rise. As such, critical action is needed on many fronts to reshape how a society thinks, discusses, and fights cancer especially as the population grows and ages. Cancer can be described as a broken social contract that requires different conceptual frameworks such as game theory. To this end, it is our hope that this perspective will catalyze a discussion to rethink the way we approach, communicate, and fund cancer research; thinking of cancer as a broken social contract is only one example. Importantly, this endeavor will require infusion of ideas from other fields such as physics, computational medicine, complexity science, agent-based modeling, sociology, and ecology, all of which have the capacity to drive new insights into cancer biology and clinical medicine.
UR - http://www.scopus.com/inward/record.url?scp=85052861240&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052861240&partnerID=8YFLogxK
U2 - 10.1158/1541-7786.MCR-18-0013
DO - 10.1158/1541-7786.MCR-18-0013
M3 - Review article
C2 - 29784670
AN - SCOPUS:85052861240
SN - 1541-7786
VL - 16
SP - 1346
EP - 1347
JO - Molecular Cancer Research
JF - Molecular Cancer Research
IS - 9
ER -