Cancer and Scleroderma

Research output: Contribution to journalReview articlepeer-review

Abstract

Individuals with scleroderma have an increased risk of cancer compared with the general population. This heightened risk may be from chronic inflammation and tissue damage, malignant transformation provoked by immunosuppressive therapies, or a common inciting factor. In unique subsets of patients with scleroderma, there is a close temporal relationship between the onset of cancer and scleroderma, suggesting cancer-induced autoimmunity. This article discusses the potential mechanistic links between cancer and scleroderma, the serologic and clinical risk factors associated with increased cancer risk in patients with scleroderma, and implications for cancer screening.

Original languageEnglish (US)
Pages (from-to)551-564
Number of pages14
JournalRheumatic Disease Clinics of North America
Volume46
Issue number3
DOIs
StatePublished - Aug 2020

Keywords

  • Autoantibodies
  • Cancer screening
  • Epidemiology
  • Malignancy
  • Scleroderma

ASJC Scopus subject areas

  • Rheumatology

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