Cancer and Scleroderma

Emma Weeding; Livia Casciola-Rosen; Ami A. Shah

doi:10.1016/j.rdc.2020.03.002

Cancer and Scleroderma

Emma Weeding, Livia Casciola-Rosen, Ami A. Shah

School of Medicine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Individuals with scleroderma have an increased risk of cancer compared with the general population. This heightened risk may be from chronic inflammation and tissue damage, malignant transformation provoked by immunosuppressive therapies, or a common inciting factor. In unique subsets of patients with scleroderma, there is a close temporal relationship between the onset of cancer and scleroderma, suggesting cancer-induced autoimmunity. This article discusses the potential mechanistic links between cancer and scleroderma, the serologic and clinical risk factors associated with increased cancer risk in patients with scleroderma, and implications for cancer screening.

Original language	English (US)
Pages (from-to)	551-564
Number of pages	14
Journal	Rheumatic Disease Clinics of North America
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.rdc.2020.03.002
State	Published - Aug 2020

Keywords

Autoantibodies
Cancer screening
Epidemiology
Malignancy
Scleroderma

ASJC Scopus subject areas

Rheumatology

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10.1016/j.rdc.2020.03.002

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title = "Cancer and Scleroderma",

abstract = "Individuals with scleroderma have an increased risk of cancer compared with the general population. This heightened risk may be from chronic inflammation and tissue damage, malignant transformation provoked by immunosuppressive therapies, or a common inciting factor. In unique subsets of patients with scleroderma, there is a close temporal relationship between the onset of cancer and scleroderma, suggesting cancer-induced autoimmunity. This article discusses the potential mechanistic links between cancer and scleroderma, the serologic and clinical risk factors associated with increased cancer risk in patients with scleroderma, and implications for cancer screening.",

keywords = "Autoantibodies, Cancer screening, Epidemiology, Malignancy, Scleroderma",

author = "Emma Weeding and Livia Casciola-Rosen and Shah, {Ami A.}",

note = "Funding Information: Funding: This work was supported by grants from the NIH /NIAMS ( R01 AR073208 ) and the Donald B. and Dorothy L. Stabler Foundation . Funding Information: Funding: This work was supported by grants from the NIH/NIAMS (R01 AR073208) and the Donald B. and Dorothy L. Stabler Foundation. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = aug,

doi = "10.1016/j.rdc.2020.03.002",

language = "English (US)",

volume = "46",

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journal = "Rheumatic Disease Clinics of North America",

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AU - Weeding, Emma

AU - Casciola-Rosen, Livia

AU - Shah, Ami A.

N1 - Funding Information: Funding: This work was supported by grants from the NIH /NIAMS ( R01 AR073208 ) and the Donald B. and Dorothy L. Stabler Foundation . Funding Information: Funding: This work was supported by grants from the NIH/NIAMS (R01 AR073208) and the Donald B. and Dorothy L. Stabler Foundation. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2020/8

Y1 - 2020/8

N2 - Individuals with scleroderma have an increased risk of cancer compared with the general population. This heightened risk may be from chronic inflammation and tissue damage, malignant transformation provoked by immunosuppressive therapies, or a common inciting factor. In unique subsets of patients with scleroderma, there is a close temporal relationship between the onset of cancer and scleroderma, suggesting cancer-induced autoimmunity. This article discusses the potential mechanistic links between cancer and scleroderma, the serologic and clinical risk factors associated with increased cancer risk in patients with scleroderma, and implications for cancer screening.

AB - Individuals with scleroderma have an increased risk of cancer compared with the general population. This heightened risk may be from chronic inflammation and tissue damage, malignant transformation provoked by immunosuppressive therapies, or a common inciting factor. In unique subsets of patients with scleroderma, there is a close temporal relationship between the onset of cancer and scleroderma, suggesting cancer-induced autoimmunity. This article discusses the potential mechanistic links between cancer and scleroderma, the serologic and clinical risk factors associated with increased cancer risk in patients with scleroderma, and implications for cancer screening.

KW - Autoantibodies

KW - Cancer screening

KW - Epidemiology

KW - Malignancy

KW - Scleroderma

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Cancer and Scleroderma

Abstract

Keywords

ASJC Scopus subject areas

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