Cancer and Immune System

Basic Concepts and Targets for Intervention

Research output: Contribution to journalArticle

Abstract

A number of consensuses regarding cancer immunology have recently emerged from both preclinical immunorapy models and analysis of cancer patients. First and foremost, natural state of endogenous tumor reactive T cells is characterized by general hyporesponsiveness or anergy. This is likely due to a number of mechanisms that tumors use to induce tolerance as y develop. While many of newer generation vaccines can effectively transfer antigen to and activate dendritic cells, T-cell tolerance remains a major barrier that is difficult to overcome by vaccination alone. Preclinical models demonstrate that for poorly immunogenic tumors, once tolerance has been established, rapeutic vaccines alone are ineffective at curing animals with a significant established tumor burden. However, combination strategies of vaccination toger with inhibitors of immunologic checkpoints and agonists for co-stimulatory pathways are proving capable of overcoming tolerance and generating significant anti-tumor responses even in cases of established metastatic cancer.

Original languageEnglish (US)
Pages (from-to)523-538
Number of pages16
JournalSeminars in Oncology
Volume42
Issue number4
DOIs
StatePublished - Aug 1 2015

Fingerprint

Immune System Phenomena
Neoplasms
Vaccination
Vaccines
T-Lymphocytes
Allergy and Immunology
Tumor Burden
Dendritic Cells
Antigens

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Medicine(all)

Cite this

Cancer and Immune System : Basic Concepts and Targets for Intervention. / Pardoll, Andrew Mark.

In: Seminars in Oncology, Vol. 42, No. 4, 01.08.2015, p. 523-538.

Research output: Contribution to journalArticle

@article{4fafa56d6157463cab81ed2e3523b8a9,
title = "Cancer and Immune System: Basic Concepts and Targets for Intervention",
abstract = "A number of consensuses regarding cancer immunology have recently emerged from both preclinical immunorapy models and analysis of cancer patients. First and foremost, natural state of endogenous tumor reactive T cells is characterized by general hyporesponsiveness or anergy. This is likely due to a number of mechanisms that tumors use to induce tolerance as y develop. While many of newer generation vaccines can effectively transfer antigen to and activate dendritic cells, T-cell tolerance remains a major barrier that is difficult to overcome by vaccination alone. Preclinical models demonstrate that for poorly immunogenic tumors, once tolerance has been established, rapeutic vaccines alone are ineffective at curing animals with a significant established tumor burden. However, combination strategies of vaccination toger with inhibitors of immunologic checkpoints and agonists for co-stimulatory pathways are proving capable of overcoming tolerance and generating significant anti-tumor responses even in cases of established metastatic cancer.",
author = "Pardoll, {Andrew Mark}",
year = "2015",
month = "8",
day = "1",
doi = "10.1053/j.seminoncol.2015.05.003",
language = "English (US)",
volume = "42",
pages = "523--538",
journal = "Seminars in Oncology",
issn = "0093-7754",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Cancer and Immune System

T2 - Basic Concepts and Targets for Intervention

AU - Pardoll, Andrew Mark

PY - 2015/8/1

Y1 - 2015/8/1

N2 - A number of consensuses regarding cancer immunology have recently emerged from both preclinical immunorapy models and analysis of cancer patients. First and foremost, natural state of endogenous tumor reactive T cells is characterized by general hyporesponsiveness or anergy. This is likely due to a number of mechanisms that tumors use to induce tolerance as y develop. While many of newer generation vaccines can effectively transfer antigen to and activate dendritic cells, T-cell tolerance remains a major barrier that is difficult to overcome by vaccination alone. Preclinical models demonstrate that for poorly immunogenic tumors, once tolerance has been established, rapeutic vaccines alone are ineffective at curing animals with a significant established tumor burden. However, combination strategies of vaccination toger with inhibitors of immunologic checkpoints and agonists for co-stimulatory pathways are proving capable of overcoming tolerance and generating significant anti-tumor responses even in cases of established metastatic cancer.

AB - A number of consensuses regarding cancer immunology have recently emerged from both preclinical immunorapy models and analysis of cancer patients. First and foremost, natural state of endogenous tumor reactive T cells is characterized by general hyporesponsiveness or anergy. This is likely due to a number of mechanisms that tumors use to induce tolerance as y develop. While many of newer generation vaccines can effectively transfer antigen to and activate dendritic cells, T-cell tolerance remains a major barrier that is difficult to overcome by vaccination alone. Preclinical models demonstrate that for poorly immunogenic tumors, once tolerance has been established, rapeutic vaccines alone are ineffective at curing animals with a significant established tumor burden. However, combination strategies of vaccination toger with inhibitors of immunologic checkpoints and agonists for co-stimulatory pathways are proving capable of overcoming tolerance and generating significant anti-tumor responses even in cases of established metastatic cancer.

UR - http://www.scopus.com/inward/record.url?scp=84940379785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940379785&partnerID=8YFLogxK

U2 - 10.1053/j.seminoncol.2015.05.003

DO - 10.1053/j.seminoncol.2015.05.003

M3 - Article

VL - 42

SP - 523

EP - 538

JO - Seminars in Oncology

JF - Seminars in Oncology

SN - 0093-7754

IS - 4

ER -