Cancer and autoimmunity: Harnessing longitudinal cohorts to probe the link

Giordano Egiziano, Sasha Bernatsky, Ami Shah

Research output: Contribution to journalArticle

Abstract

In many autoimmune rheumatic diseases, there is an increased risk of cancer compared to the general population. While reasons for this increased risk have not been elucidated, it has been hypothesized that the link between cancer and autoimmunity may be bidirectional. For instance, chronic inflammation and damage from the rheumatic disease or its therapies may trigger malignant transformation; conversely, antitumor immune responses targeting cancers may become cross-reactive resulting in autoimmunity. In rare rheumatic diseases, longitudinal observational studies can play a critical role in studying these complex relationships, thereby enabling investigators to quantify the extent of cancer risk, identify unique clinical phenotypes associated with cancer, investigate the biological link between these conditions, and define optimal strategies for screening and treatment of the underlying cancer. In this review, we discuss recent data on cancer in the rheumatic diseases and suggest a research agenda to address several gaps in our current knowledge base.

Original languageEnglish (US)
JournalBest Practice and Research: Clinical Rheumatology
DOIs
StateAccepted/In press - 2016

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Autoimmunity
Rheumatic Diseases
Neoplasms
Knowledge Bases
Rare Diseases
Autoimmune Diseases
Observational Studies
Longitudinal Studies
Research Personnel
Inflammation
Phenotype
Research
Population

Keywords

  • Autoimmunity
  • Cancer
  • Epidemiology
  • Observational cohorts

ASJC Scopus subject areas

  • Rheumatology

Cite this

Cancer and autoimmunity : Harnessing longitudinal cohorts to probe the link. / Egiziano, Giordano; Bernatsky, Sasha; Shah, Ami.

In: Best Practice and Research: Clinical Rheumatology, 2016.

Research output: Contribution to journalArticle

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