Can we screen high-risk individuals to detect early pancreatic carcinoma?

Research output: Contribution to journalReview article

Abstract

An estimated 10% of individuals with pancreatic cancer have an inherited predisposition to the disease. Germline mutations in BRCA2, p16, STK11, and the cationic trypsinogen gene contribute to inherited forms of pancreatic cancer, but the gene(s) responsible for much of the familial pancreatic cancer burden remains to be identified. The high lifetime risk of pancreatic cancer that exists among at-risk members of families with multiple pancreatic cancers highlights the pressing need for pancreatic cancer early detection strategies. Since curative pancreatic resection is still the only curative treatment for most patients with pancreatic cancer, the early detection of symptomless pancreatic cancer using endoscopic ultrasound or molecular markers may provide the best chance of cure for individuals at high risk of this disease. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalJournal of Surgical Oncology
Volume74
Issue number4
DOIs
StatePublished - Sep 11 2000

Keywords

  • BRCA2
  • DNA methylation
  • Endoscopic ultrasound
  • Familial pancreatic cancer
  • Hereditary pancreatitis
  • Screening
  • Telomerase
  • p16

ASJC Scopus subject areas

  • Surgery
  • Oncology

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