Can the Risk of Non-home Discharge After Resection of Gastric Adenocarcinoma Be Predicted: a Seven-Institution Study of the US Gastric Cancer Collaborative

Alexandra W. Acher, Malcolm H. Squires, Ryan C. Fields, George A. Poultsides, Carl Schmidt, Konstantinos I. Votanopoulos, Timothy M. Pawlik, Linda X. Jin, Aslam Ejaz, David A. Kooby, Mark Bloomston, David Worhunsky, Edward A. Levine, Neil Saunders, Emily Winslow, Clifford S. Cho, Ken Meredith, Glen Leverson, Shishir K. Maithel, Sharon M. Weber

Research output: Contribution to journalArticle

Abstract

Background: There are no validated methods to preoperatively identify patients with increased risk of discharge to skilled nursing facilities following resection of gastric cancer. We sought to identify preoperative predictors of non-home discharge to optimize transition of care to skilled nursing facility.Methods: Patients who underwent resection of gastric cancer from 2000 to 2012 from seven participating institutions of the US Gastric Cancer Collaborative were analyzed. Fisher’s exact tests, Student t tests, and logistic regression analyses identified preoperative variables associated with non-home discharge. A prediction tool was created and validated through c-indices. Survival analysis was conducted according to the methods of Kaplan and Meier.Results: Out of the 918 patients identified, 93 (10 %) were discharged to nonhome location. Univariate analysis identified advancing age, American Society of Anesthesiology (ASA) score, hypertension, decreasing preoperative albumin, and lack of neoadjuvant chemotherapy as risk factors for non-home discharge (NHD). Multivariable analysis identified advanced age (odds ratio (OR) = 1.07, 95 % confidence interval (CI) = 1.04–1.10, p <0.0001), depressed preoperative albumin (OR = 2.17, 95 % CI = 1.47–3.19, p = 0.0001), and total gastrectomy (OR = 2.56, 95 % CI = 1.53–4.3, p = 0.0003) as risk factors for NHD. The c-index of the model and the validation population were 0.76 and 0.8, respectively. Additionally, there was an association of decreased overall survival in patients discharged to nonhome location (35.5 months, home discharge, vs 12 months, NHD, p <0.0001).Conclusions: Older patients with compromised nutritional status have greater risk of NHD following resection of gastric cancer. The prediction tool can augment preoperative planning to optimize transition of care to skilled nursing facility.

Original languageEnglish (US)
Pages (from-to)207-216
Number of pages10
JournalJournal of Gastrointestinal Surgery
Volume19
Issue number2
DOIs
StatePublished - 2015

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Stomach Neoplasms
Skilled Nursing Facilities
Stomach
Adenocarcinoma
Patient Transfer
Odds Ratio
Confidence Intervals
Albumins
Anesthesiology
Gastrectomy
Survival Analysis
Nutritional Status
Logistic Models
Regression Analysis
Students
Hypertension
Drug Therapy
Survival
Population

Keywords

  • Adenocarcinoma
  • Advanced age
  • Albumin
  • Discharge
  • Gastric cancer
  • Preoperative
  • Risk factors

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Can the Risk of Non-home Discharge After Resection of Gastric Adenocarcinoma Be Predicted : a Seven-Institution Study of the US Gastric Cancer Collaborative. / Acher, Alexandra W.; Squires, Malcolm H.; Fields, Ryan C.; Poultsides, George A.; Schmidt, Carl; Votanopoulos, Konstantinos I.; Pawlik, Timothy M.; Jin, Linda X.; Ejaz, Aslam; Kooby, David A.; Bloomston, Mark; Worhunsky, David; Levine, Edward A.; Saunders, Neil; Winslow, Emily; Cho, Clifford S.; Meredith, Ken; Leverson, Glen; Maithel, Shishir K.; Weber, Sharon M.

In: Journal of Gastrointestinal Surgery, Vol. 19, No. 2, 2015, p. 207-216.

Research output: Contribution to journalArticle

Acher, AW, Squires, MH, Fields, RC, Poultsides, GA, Schmidt, C, Votanopoulos, KI, Pawlik, TM, Jin, LX, Ejaz, A, Kooby, DA, Bloomston, M, Worhunsky, D, Levine, EA, Saunders, N, Winslow, E, Cho, CS, Meredith, K, Leverson, G, Maithel, SK & Weber, SM 2015, 'Can the Risk of Non-home Discharge After Resection of Gastric Adenocarcinoma Be Predicted: a Seven-Institution Study of the US Gastric Cancer Collaborative', Journal of Gastrointestinal Surgery, vol. 19, no. 2, pp. 207-216. https://doi.org/10.1007/s11605-014-2690-2
Acher, Alexandra W. ; Squires, Malcolm H. ; Fields, Ryan C. ; Poultsides, George A. ; Schmidt, Carl ; Votanopoulos, Konstantinos I. ; Pawlik, Timothy M. ; Jin, Linda X. ; Ejaz, Aslam ; Kooby, David A. ; Bloomston, Mark ; Worhunsky, David ; Levine, Edward A. ; Saunders, Neil ; Winslow, Emily ; Cho, Clifford S. ; Meredith, Ken ; Leverson, Glen ; Maithel, Shishir K. ; Weber, Sharon M. / Can the Risk of Non-home Discharge After Resection of Gastric Adenocarcinoma Be Predicted : a Seven-Institution Study of the US Gastric Cancer Collaborative. In: Journal of Gastrointestinal Surgery. 2015 ; Vol. 19, No. 2. pp. 207-216.
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abstract = "Background: There are no validated methods to preoperatively identify patients with increased risk of discharge to skilled nursing facilities following resection of gastric cancer. We sought to identify preoperative predictors of non-home discharge to optimize transition of care to skilled nursing facility.Methods: Patients who underwent resection of gastric cancer from 2000 to 2012 from seven participating institutions of the US Gastric Cancer Collaborative were analyzed. Fisher’s exact tests, Student t tests, and logistic regression analyses identified preoperative variables associated with non-home discharge. A prediction tool was created and validated through c-indices. Survival analysis was conducted according to the methods of Kaplan and Meier.Results: Out of the 918 patients identified, 93 (10 {\%}) were discharged to nonhome location. Univariate analysis identified advancing age, American Society of Anesthesiology (ASA) score, hypertension, decreasing preoperative albumin, and lack of neoadjuvant chemotherapy as risk factors for non-home discharge (NHD). Multivariable analysis identified advanced age (odds ratio (OR) = 1.07, 95 {\%} confidence interval (CI) = 1.04–1.10, p <0.0001), depressed preoperative albumin (OR = 2.17, 95 {\%} CI = 1.47–3.19, p = 0.0001), and total gastrectomy (OR = 2.56, 95 {\%} CI = 1.53–4.3, p = 0.0003) as risk factors for NHD. The c-index of the model and the validation population were 0.76 and 0.8, respectively. Additionally, there was an association of decreased overall survival in patients discharged to nonhome location (35.5 months, home discharge, vs 12 months, NHD, p <0.0001).Conclusions: Older patients with compromised nutritional status have greater risk of NHD following resection of gastric cancer. The prediction tool can augment preoperative planning to optimize transition of care to skilled nursing facility.",
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T2 - a Seven-Institution Study of the US Gastric Cancer Collaborative

AU - Acher, Alexandra W.

AU - Squires, Malcolm H.

AU - Fields, Ryan C.

AU - Poultsides, George A.

AU - Schmidt, Carl

AU - Votanopoulos, Konstantinos I.

AU - Pawlik, Timothy M.

AU - Jin, Linda X.

AU - Ejaz, Aslam

AU - Kooby, David A.

AU - Bloomston, Mark

AU - Worhunsky, David

AU - Levine, Edward A.

AU - Saunders, Neil

AU - Winslow, Emily

AU - Cho, Clifford S.

AU - Meredith, Ken

AU - Leverson, Glen

AU - Maithel, Shishir K.

AU - Weber, Sharon M.

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