Can imaging modalities diagnose and stage hepatic fibrosis and cirrhosis accurately?

Susanne Bonekamp, Ihab R Kamel, Steven Solga, Jeanne Clark

Research output: Contribution to journalArticle

Abstract

The accurate diagnosis and staging of hepatic fibrosis is crucial for prognosis and treatment of liver disease. The current gold standard, liver biopsy, cannot be used for population-based screening, and has well known drawbacks if used for monitoring of disease progression or treatment success. Our objective was to assess performance and promise of radiologic modalities and techniques as alternative, noninvasive assessment of hepatic fibrosis. A systematic review was conducted. Six hundred twenty-eight studies were identified via electronic search. One hundred fifty-three papers were reviewed. Most described techniques that could differentiate between cirrhosis or severe fibrosis and normal liver. Accurate staging of fibrosis or diagnosis of mild fibrosis was often not achievable. Ultrasonography is the most common modality used in the diagnosis and staging of hepatic fibrosis. Elastographic measurements, either ultrasonography-based or magnetic resonance-based, and magnetic resonance diffusion weighted imaging, show the most promise for accurate staging of hepatic fibrosis. Most currently available imaging techniques can detect cirrhosis or significant fibrosis reasonably accurately. However, to date only magnetic resonance elastography has been able to stage fibrosis or diagnose mild disease. Utrasonographic elastography and magnetic resonance diffusion weighted appear next most promising.

Original languageEnglish (US)
Pages (from-to)17-35
Number of pages19
JournalJournal of Hepatology
Volume50
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

Liver Cirrhosis
Fibrosis
Liver
Elasticity Imaging Techniques
Ultrasonography
Diffusion Magnetic Resonance Imaging
Disease Progression
Liver Diseases
Magnetic Resonance Spectroscopy
Biopsy

Keywords

  • Fibrosis
  • Imaging
  • Radiology

ASJC Scopus subject areas

  • Hepatology

Cite this

Can imaging modalities diagnose and stage hepatic fibrosis and cirrhosis accurately? / Bonekamp, Susanne; Kamel, Ihab R; Solga, Steven; Clark, Jeanne.

In: Journal of Hepatology, Vol. 50, No. 1, 01.2009, p. 17-35.

Research output: Contribution to journalArticle

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