Can emotional and behavioral dysregulation in youth be decoded from functional neuroimaging?

Liana C.L. Portugal, Maria João Rosa, Anil Rao, Genna Bebko, Michele A. Bertocci, Amanda K. Hinze, Lisa Bonar, Jorge R.C. Almeida, Susan B. Perlman, Amelia Versace, Claudiu Schirda, Michael Travis, Mary Kay Gill, Christine Demeter, Vaibhav A. Diwadkar, Gary Ciuffetelli, Eric Rodriguez, Erika E. Forbes, Jeffrey L. Sunshine, Scott K. HollandRobert A. Kowatch, Boris Birmaher, David Axelson, Sarah M. Horwitz, Eugene L. Arnold, Mary A. Fristad, Eric A. Youngstrom, Robert L. Findling, Mirtes Pereira, Leticia Oliveira, Mary L. Phillips, Janaina Mourao-Miranda

Research output: Contribution to journalArticle

Abstract

Introduction High comorbidity among pediatric disorders characterized by behavioral and emotional dysregulation poses problems for diagnosis and treatment, and suggests that these disorders may be better conceptualized as dimensions of abnormal behaviors. Furthermore, identifying neuroimaging biomarkers related to dimensional measures of behavior may provide targets to guide individualized treatment. We aimed to use functional neuroimaging and pattern regression techniques to determine whether patterns of brain activity could accurately decode individual-level severity on a dimensional scale measuring behavioural and emotional dysregulation at two different time points. Methods A sample of fifty-seven youth (mean age: 14.5 years; 32 males) was selected from a multisite study of youth with parent-reported behavioral and emotional dysregulation. Participants performed a block-design reward paradigm during functional Magnetic Resonance Imaging (fMRI). Pattern regression analyses consisted of Relevance Vector Regression (RVR) and two cross-validation strategies implemented in the Pattern Recognition for Neuroimaging toolbox (PRoNTo). Medication was treated as a binary confounding variable. Decoded and actual clinical scores were compared using Pearson's correlation coefficient (r) and mean squared error (MSE) to evaluate the models. Permutation test was applied to estimate significance levels. Results Relevance Vector Regression identified patterns of neural activity associated with symptoms of behavioral and emotional dysregulation at the initial study screen and close to the fMRI scanning session. The correlation and the mean squared error between actual and decoded symptoms were significant at the initial study screen and close to the fMRI scanning session. However, after controlling for potential medication effects, results remained significant only for decoding symptoms at the initial study screen. Neural regions with the highest contribution to the pattern regression model included cerebellum, sensory-motor and fronto-limbic areas. Conclusions The combination of pattern regression models and neuroimaging can help to determine the severity of behavioral and emotional dysregulation in youth at different time points. Copyright:

Original languageEnglish (US)
Article numbere0117603
JournalPloS one
Volume11
Issue number1
DOIs
StatePublished - Jan 5 2016

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Portugal, L. C. L., Rosa, M. J., Rao, A., Bebko, G., Bertocci, M. A., Hinze, A. K., Bonar, L., Almeida, J. R. C., Perlman, S. B., Versace, A., Schirda, C., Travis, M., Gill, M. K., Demeter, C., Diwadkar, V. A., Ciuffetelli, G., Rodriguez, E., Forbes, E. E., Sunshine, J. L., ... Mourao-Miranda, J. (2016). Can emotional and behavioral dysregulation in youth be decoded from functional neuroimaging? PloS one, 11(1), [e0117603]. https://doi.org/10.1371/journal.pone.0117603