Can axillary dissection be avoided in patients with sentinel lymph node metastasis?

Angela Katz, Andrzej Niemierko, Irene Gage, Sheila Evans, Margaret Shaffer, Thomas Fleury, Frederick P. Smith, Peter E. Petrucci, Richard Flax, Cynthia Drogula, Colette Magnant

Research output: Contribution to journalArticle

Abstract

Background: Who should undergo a completion dissection following identification of a +sentinel lymph node (SLN) is controversial. Methods: The records of 1,133 patients who underwent SLN mapping were reviewed. The association between patient, tumor, and treatment characteristics and the presence of +SLNs and +nonSLNs was analyzed using two-way tables of frequency counts and Pearson χ2 test. Possible predictors of +SLNs and +nonSLNs were analyzed using simple and multiple logistic regression, Results: One thousand one hundred forty-eight SLN procedures were performed. 367 procedures (32%) yielded +SLNs. For patients with a +SLN, on multiple logistic regression analysis LVSI, increasing numbers of +SLNs, decreasing numbers of negative SLNs, and increasing size of the largest SLN metastasis were statistically significantly associated with increased likelihood of nonSLN involvement. No subgroup was identified that did not have a significant rate of nonSLN involvement on completion axillary dissection, except those who had a large number of negative SLNs (≥3) and small size of the largest SLN metastasis (

Original languageEnglish (US)
Pages (from-to)550-558
Number of pages9
JournalJournal of Surgical Oncology
Volume93
Issue number7
DOIs
StatePublished - Jun 1 2006
Externally publishedYes

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Dissection
Neoplasm Metastasis
Logistic Models
Sentinel Lymph Node
Regression Analysis
Neoplasms
Therapeutics

Keywords

  • Axillary dissection
  • Breast cancer
  • Sentinel lymph node

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Katz, A., Niemierko, A., Gage, I., Evans, S., Shaffer, M., Fleury, T., ... Magnant, C. (2006). Can axillary dissection be avoided in patients with sentinel lymph node metastasis? Journal of Surgical Oncology, 93(7), 550-558. https://doi.org/10.1002/jso.20514

Can axillary dissection be avoided in patients with sentinel lymph node metastasis? / Katz, Angela; Niemierko, Andrzej; Gage, Irene; Evans, Sheila; Shaffer, Margaret; Fleury, Thomas; Smith, Frederick P.; Petrucci, Peter E.; Flax, Richard; Drogula, Cynthia; Magnant, Colette.

In: Journal of Surgical Oncology, Vol. 93, No. 7, 01.06.2006, p. 550-558.

Research output: Contribution to journalArticle

Katz, A, Niemierko, A, Gage, I, Evans, S, Shaffer, M, Fleury, T, Smith, FP, Petrucci, PE, Flax, R, Drogula, C & Magnant, C 2006, 'Can axillary dissection be avoided in patients with sentinel lymph node metastasis?', Journal of Surgical Oncology, vol. 93, no. 7, pp. 550-558. https://doi.org/10.1002/jso.20514
Katz, Angela ; Niemierko, Andrzej ; Gage, Irene ; Evans, Sheila ; Shaffer, Margaret ; Fleury, Thomas ; Smith, Frederick P. ; Petrucci, Peter E. ; Flax, Richard ; Drogula, Cynthia ; Magnant, Colette. / Can axillary dissection be avoided in patients with sentinel lymph node metastasis?. In: Journal of Surgical Oncology. 2006 ; Vol. 93, No. 7. pp. 550-558.
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AU - Katz, Angela

AU - Niemierko, Andrzej

AU - Gage, Irene

AU - Evans, Sheila

AU - Shaffer, Margaret

AU - Fleury, Thomas

AU - Smith, Frederick P.

AU - Petrucci, Peter E.

AU - Flax, Richard

AU - Drogula, Cynthia

AU - Magnant, Colette

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AB - Background: Who should undergo a completion dissection following identification of a +sentinel lymph node (SLN) is controversial. Methods: The records of 1,133 patients who underwent SLN mapping were reviewed. The association between patient, tumor, and treatment characteristics and the presence of +SLNs and +nonSLNs was analyzed using two-way tables of frequency counts and Pearson χ2 test. Possible predictors of +SLNs and +nonSLNs were analyzed using simple and multiple logistic regression, Results: One thousand one hundred forty-eight SLN procedures were performed. 367 procedures (32%) yielded +SLNs. For patients with a +SLN, on multiple logistic regression analysis LVSI, increasing numbers of +SLNs, decreasing numbers of negative SLNs, and increasing size of the largest SLN metastasis were statistically significantly associated with increased likelihood of nonSLN involvement. No subgroup was identified that did not have a significant rate of nonSLN involvement on completion axillary dissection, except those who had a large number of negative SLNs (≥3) and small size of the largest SLN metastasis (

KW - Axillary dissection

KW - Breast cancer

KW - Sentinel lymph node

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