Can anti-Mullerian hormone (AMH) predict the outcome of intrauterine insemination with controlled ovarian stimulation?

Panagiotis Bakas, Ioannis Boutas, Maria Creatsa, Nicos Vlahos, Odysseas Gregoriou, George Creatsas, Dimitrios Hassiakos

Research output: Contribution to journalArticle

Abstract

Objective: To assess whether the levels of anti-Mullerian hormone (AMH) are related to outcome of intrauterine insemination (IUI) in patients treated with gonadotropins.Intervention(s): A total of 195 patients underwent controlled ovarian stimulation (COS) with recombinant follicle stimulating hormone (rFSH) (50-150 IU/d). All patients were submitted upto three cycles of IUI.Outcome: Primary outcome was the ability of AMH levels to predict clinical pregnancy at first attempt and the cumulative clinical pregnancy probability of upto three IUI cycles. Secondary outcomes were the relation of AMH, LH, FSH, BMI, age, parity and basic estradiol levels with each other and the outcome of IUI.Results: The area under the receiver operating characteristic (ROC) curve in predicting clinical pregnancy for AMH at first attempt was 0.53 and for cumulative clinical pregnancy was 0.76. AMH levels were positively correlated with clinical pregnancy rate at first attempt and with cumulative clinical pregnancy rate, but negatively correlated with patients age and FSH levels. Patients FSH, LH levels were negatively correlated with cumulative clinical pregnancy rate.Conclusions: AMH levels seem to have a positive correlation and patients age and LH levels had a negative correlation with the outcome of IUI and COS with gonadotropins. AMH concentration was significantly higher and LH was significantly lower in patients with a clinical pregnancy after three cycles of IUI treatment compared with those who did not achieve pregnancy.

Original languageEnglish (US)
Pages (from-to)765-768
Number of pages4
JournalGynecological Endocrinology
Volume31
Issue number10
DOIs
StatePublished - Oct 3 2015
Externally publishedYes

Fingerprint

Anti-Mullerian Hormone
Ovulation Induction
Insemination
Pregnancy
Pregnancy Rate
Gonadotropins
Follicle Stimulating Hormone
Parity
ROC Curve
Estradiol

Keywords

  • Assisted reproductive technology
  • estrogens
  • infertility

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Obstetrics and Gynecology

Cite this

Can anti-Mullerian hormone (AMH) predict the outcome of intrauterine insemination with controlled ovarian stimulation? / Bakas, Panagiotis; Boutas, Ioannis; Creatsa, Maria; Vlahos, Nicos; Gregoriou, Odysseas; Creatsas, George; Hassiakos, Dimitrios.

In: Gynecological Endocrinology, Vol. 31, No. 10, 03.10.2015, p. 765-768.

Research output: Contribution to journalArticle

Bakas, P, Boutas, I, Creatsa, M, Vlahos, N, Gregoriou, O, Creatsas, G & Hassiakos, D 2015, 'Can anti-Mullerian hormone (AMH) predict the outcome of intrauterine insemination with controlled ovarian stimulation?', Gynecological Endocrinology, vol. 31, no. 10, pp. 765-768. https://doi.org/10.3109/09513590.2015.1025381
Bakas, Panagiotis ; Boutas, Ioannis ; Creatsa, Maria ; Vlahos, Nicos ; Gregoriou, Odysseas ; Creatsas, George ; Hassiakos, Dimitrios. / Can anti-Mullerian hormone (AMH) predict the outcome of intrauterine insemination with controlled ovarian stimulation?. In: Gynecological Endocrinology. 2015 ; Vol. 31, No. 10. pp. 765-768.
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