Can amide proton transfer–weighted imaging differentiate tumor grade and predict Ki-67 proliferation status of meningioma?

Hao Yu, Xinrui Wen, Pingping Wu, Yueqin Chen, Tianyu Zou, Xianlong Wang, Shanshan Jiang, Jinyuan Zhou, Zhibo Wen

Research output: Contribution to journalArticle

Abstract

Objectives: To determine the utility of the amide proton transfer–weighted MR imaging in differentiating the WHO grade and predict proliferative activity of meningioma. Methods: Fifty-three patients with WHO grade I meningiomas and 26 patients with WHO grade II meningiomas underwent conventional and APT-weighted sequences on a 3.0 Tesla MR before clinical intervention. The APT-weighted (APTw) parameters in the solid tumor region were obtained and compared between two grades using the t test; the receiver operating characteristic (ROC) curve was used to assess the best parameter for predicting the grade of meningiomas. Pearson’s correlation coefficient was calculated between the APTwmax and Ki-67 labeling index in meningiomas. Results: The APTwmax and APTwmean values were not significantly different between WHO grade I and grade II meningiomas (p = 0.103 and p = 0.318). The APTwmin value was higher and the APTwmax-min value was lower in WHO grade II meningiomas than in WHO grade I tumors (p = 0.027 and p = 0.019). But the APTwmin was higher and the APTwmax-min was lower in microcystic meningiomas than in WHO grade II meningiomas (p = 0.001 and p = 0.006). The APTwmin combined with APTwmax-min showed the best diagnostic performance in predicting the grade of meningiomas with an AUC of 0.772. The APTwmax value was positively correlated with Ki-67 labeling index (r = 0.817, p < 0.001) in meningiomas; the regression equation for the Ki-67 labeling index (%) (Y) and APTwmax (%) (X) was Y = 4.9 × X − 12.4 (R2 = 0.667, p < 0.001). Conclusion: As a noninvasive imaging method, the ability of APTw-MR imaging in differentiating the grade of meningiomas is limited, but the technology can be used to predict the proliferative activity of meningioma. Key Points: • The APTwminvalue was higher and the APTwmax-minvalue was lower in WHO grade II meningioma than in grade I tumors. • The APTwminvalue was higher and the APTwmax-minvalue was lower in microcystic meningiomas than in WHO grade II meningiomas. • The APTwmaxvalue was positively correlated with meningioma proliferation index.

Original languageEnglish (US)
Pages (from-to)5298-5306
Number of pages9
JournalEuropean radiology
Volume29
Issue number10
DOIs
StatePublished - Oct 1 2019

Keywords

  • Amide proton transfer
  • Cell proliferation
  • Magnetic resonance imaging
  • Meningioma
  • Tumor grading

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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