Can a simple test of functional capacity add to the clinical assessment of diabetes?

T. Stewart, D. G. Caffrey, Robert H Gilman, Stephen Mathai, A. Lerner, A. Hernandez, M. E. Pinto, Y. Huaylinos, L. Cabrera, Robert A Wise, J. J. Miranda, William Checkley

Research output: Contribution to journalArticle

Abstract

Aim: To identify impairment in functional capacity associated with complicated and non-complicated diabetes using the 6-min walk distance test. Methods: We enrolled 111 adults, aged ≥40 years, with Type 2 diabetes from a hospital facility and 150 healthy control subjects of similar age and sex from a community site in Lima, Peru. All participants completed a 6-min walk test. Results: The mean age of the 261 participants was 58.3 years, and 43.3% were male. Among those with diabetes, 67 (60%) had non-complicated diabetes and 44 (40%) had complications such as peripheral neuropathy, retinopathy or nephropathy. The mean unadjusted 6-min walk distances were 376 m and 394 m in adults with and without diabetes complications, respectively, vs 469 m in control subjects (P1c level as a covariate in multivariable regression, participants walked 13 m less far (-16.9 to -9.9 m) for each % increase in HbA1c. Conclusions: The subjects with diabetes had lower functional capacity compared with healthy control subjects with similar characteristics. Differences in 6-min walk distance were even apparent in the subjects without diabetes complications. Potential mechanisms that could explain this finding are early cardiovascular disease or deconditioning.

Original languageEnglish (US)
JournalDiabetic Medicine
DOIs
StateAccepted/In press - 2015

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Diabetes Complications
Cardiovascular Deconditioning
Healthy Volunteers
Peru
Peripheral Nervous System Diseases
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Walk Test

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Can a simple test of functional capacity add to the clinical assessment of diabetes? / Stewart, T.; Caffrey, D. G.; Gilman, Robert H; Mathai, Stephen; Lerner, A.; Hernandez, A.; Pinto, M. E.; Huaylinos, Y.; Cabrera, L.; Wise, Robert A; Miranda, J. J.; Checkley, William.

In: Diabetic Medicine, 2015.

Research output: Contribution to journalArticle

Stewart, T. ; Caffrey, D. G. ; Gilman, Robert H ; Mathai, Stephen ; Lerner, A. ; Hernandez, A. ; Pinto, M. E. ; Huaylinos, Y. ; Cabrera, L. ; Wise, Robert A ; Miranda, J. J. ; Checkley, William. / Can a simple test of functional capacity add to the clinical assessment of diabetes?. In: Diabetic Medicine. 2015.
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AU - Lerner, A.

AU - Hernandez, A.

AU - Pinto, M. E.

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AU - Wise, Robert A

AU - Miranda, J. J.

AU - Checkley, William

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N2 - Aim: To identify impairment in functional capacity associated with complicated and non-complicated diabetes using the 6-min walk distance test. Methods: We enrolled 111 adults, aged ≥40 years, with Type 2 diabetes from a hospital facility and 150 healthy control subjects of similar age and sex from a community site in Lima, Peru. All participants completed a 6-min walk test. Results: The mean age of the 261 participants was 58.3 years, and 43.3% were male. Among those with diabetes, 67 (60%) had non-complicated diabetes and 44 (40%) had complications such as peripheral neuropathy, retinopathy or nephropathy. The mean unadjusted 6-min walk distances were 376 m and 394 m in adults with and without diabetes complications, respectively, vs 469 m in control subjects (P1c level as a covariate in multivariable regression, participants walked 13 m less far (-16.9 to -9.9 m) for each % increase in HbA1c. Conclusions: The subjects with diabetes had lower functional capacity compared with healthy control subjects with similar characteristics. Differences in 6-min walk distance were even apparent in the subjects without diabetes complications. Potential mechanisms that could explain this finding are early cardiovascular disease or deconditioning.

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