cAMP-dependent growth cone guidance by netrin-1

Guo Li Ming, Hong Jun Song, Benedikt Berninger, Christine E. Holt, Marc Tessier-Lavigne, Mu Ming Poo

Research output: Contribution to journalArticle

Abstract

Netrin-1 is known to function as a chemoattractant for several classes of developing axons and as a chemorepellent for other classes of axons, apparently dependent on the receptor type expressed by responsive cells. In culture, growth cones of embryonic Xenopus spinal neurons exhibited chemoattractive turning toward the source of netrin-1 but showed chemorepulsive responses in the presence of a competitive analog of cAMP or an inhibitor of protein kinase A. Both attractive and repulsive responses were abolished by depleting extracellular calcium and by adding a blocking antibody against the netrin-1 receptor Deleted in Colorectal Cancer. Thus, nerve growth cones may respond to the same guidance cue with opposite turning behavior, dependent on other coincident signals that set the level of cytosolic cAMP.

Original languageEnglish (US)
Pages (from-to)1225-1235
Number of pages11
JournalNeuron
Volume19
Issue number6
DOIs
StatePublished - Dec 1997
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Ming, G. L., Song, H. J., Berninger, B., Holt, C. E., Tessier-Lavigne, M., & Poo, M. M. (1997). cAMP-dependent growth cone guidance by netrin-1. Neuron, 19(6), 1225-1235. https://doi.org/10.1016/S0896-6273(00)80414-6