CaMKII and its role in cardiac arrhythmia: Molecular perspectives

Jeffrey R. Erickson, Mark E. Anderson

Research output: Contribution to journalReview articlepeer-review

Abstract

CaMKII and Its Role in Cardiac Arrhythmia. Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase widely distributed in a number of tissue types. Activation of CaMKII has been linked to important downstream physiological processes, including apoptosis, hypertrophy, and arrhythmia in the heart. Pharmacological or genetic inhibition of CaMKII has been shown to improve health outcomes in a number of animal models. In this review, we summarize the structural and functional properties of CaMKII and detail its role in cardiac arrhythmia, structural heart disease, and sudden death.

Original languageEnglish (US)
Pages (from-to)1332-1336
Number of pages5
JournalJournal of cardiovascular electrophysiology
Volume19
Issue number12
DOIs
StatePublished - Dec 2008
Externally publishedYes

Keywords

  • Arrhythmia
  • CaMKII
  • Hypertrophy
  • Oxidation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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