CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction

Chad E. Grueter, Roger J. Colbran, Mark E. Anderson

Research output: Contribution to journalReview article

Abstract

Maintenance of cytoplasmic calcium homeostasis is critical for all cells. An exciting field has emerged in elucidating the multiple roles that Ca 2+/calmodulin-dependent protein kinase II (CaMKII) plays in regulating Ca2+ cycling in normal cardiac myocytes and in pathophysiological states. Moreover, CaMKII was recently identified as a potential drug target in cardiac disease. This work has given us a closer view of the complexity and therapeutic possibilities of CaMKII regulation of Ca 2+ signaling in cardiac myocytes.

Original languageEnglish (US)
Pages (from-to)5-14
Number of pages10
JournalJournal of Molecular Medicine
Volume85
Issue number1
DOIs
StatePublished - Jan 1 2007

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Keywords

  • Ca handling
  • Calmodulin-dependent protein kinase II
  • Excitation-contraction coupling
  • Heart disease

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

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