CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction

Chad E. Grueter; Roger J. Colbran; Mark E. Anderson

doi:10.1007/s00109-006-0125-6

CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction

Chad E. Grueter, Roger J. Colbran, Mark E. Anderson

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Maintenance of cytoplasmic calcium homeostasis is critical for all cells. An exciting field has emerged in elucidating the multiple roles that Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII) plays in regulating Ca²⁺ cycling in normal cardiac myocytes and in pathophysiological states. Moreover, CaMKII was recently identified as a potential drug target in cardiac disease. This work has given us a closer view of the complexity and therapeutic possibilities of CaMKII regulation of Ca ²⁺ signaling in cardiac myocytes.

Original language	English (US)
Pages (from-to)	5-14
Number of pages	10
Journal	Journal of Molecular Medicine
Volume	85
Issue number	1
DOIs	https://doi.org/10.1007/s00109-006-0125-6
State	Published - Jan 2007
Externally published	Yes

Keywords

Ca handling
Calmodulin-dependent protein kinase II
Excitation-contraction coupling
Heart disease

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Genetics(clinical)

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10.1007/s00109-006-0125-6

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title = "CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction",

abstract = "Maintenance of cytoplasmic calcium homeostasis is critical for all cells. An exciting field has emerged in elucidating the multiple roles that Ca 2+/calmodulin-dependent protein kinase II (CaMKII) plays in regulating Ca2+ cycling in normal cardiac myocytes and in pathophysiological states. Moreover, CaMKII was recently identified as a potential drug target in cardiac disease. This work has given us a closer view of the complexity and therapeutic possibilities of CaMKII regulation of Ca 2+ signaling in cardiac myocytes.",

keywords = "Ca handling, Calmodulin-dependent protein kinase II, Excitation-contraction coupling, Heart disease",

author = "Grueter, {Chad E.} and Colbran, {Roger J.} and Anderson, {Mark E.}",

note = "Funding Information: Acknowledgements Support: NIH research grants to MEA (HL062494, HL70250, and HL46681) and RJC (MH63232). MEA is an AHA-established Investigator. CEG was partially supported by an AHA Fellowship and by an NIH training grant in cardiology (HL07411).",

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doi = "10.1007/s00109-006-0125-6",

language = "English (US)",

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T1 - CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction

AU - Grueter, Chad E.

AU - Colbran, Roger J.

AU - Anderson, Mark E.

N1 - Funding Information: Acknowledgements Support: NIH research grants to MEA (HL062494, HL70250, and HL46681) and RJC (MH63232). MEA is an AHA-established Investigator. CEG was partially supported by an AHA Fellowship and by an NIH training grant in cardiology (HL07411).

PY - 2007/1

Y1 - 2007/1

N2 - Maintenance of cytoplasmic calcium homeostasis is critical for all cells. An exciting field has emerged in elucidating the multiple roles that Ca 2+/calmodulin-dependent protein kinase II (CaMKII) plays in regulating Ca2+ cycling in normal cardiac myocytes and in pathophysiological states. Moreover, CaMKII was recently identified as a potential drug target in cardiac disease. This work has given us a closer view of the complexity and therapeutic possibilities of CaMKII regulation of Ca 2+ signaling in cardiac myocytes.

AB - Maintenance of cytoplasmic calcium homeostasis is critical for all cells. An exciting field has emerged in elucidating the multiple roles that Ca 2+/calmodulin-dependent protein kinase II (CaMKII) plays in regulating Ca2+ cycling in normal cardiac myocytes and in pathophysiological states. Moreover, CaMKII was recently identified as a potential drug target in cardiac disease. This work has given us a closer view of the complexity and therapeutic possibilities of CaMKII regulation of Ca 2+ signaling in cardiac myocytes.

KW - Ca handling

KW - Calmodulin-dependent protein kinase II

KW - Excitation-contraction coupling

KW - Heart disease

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CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction

Abstract

Keywords

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