Calories and gastric emptying: A regulatory capacity with implications for feeding

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Abstract

Gastric emptying in four unanesthetized male Macaca mulatta was studied with the serial test meal method of Hunt and Spurrell. Liquid meals were infused into the stomach through a chronic indwelling Silastic cannula. Saline meals empty rapidly and exponentially. Doubling the volume of saline from 150 to 300 ml increased the emptying rate so that the half-life remained unchanged (15 min). The 150-ml glucose meals (0.05, 0.125 and 0.25 g/ml) emptied more slowly than saline, progressively more slowly with increasing concentrations (0.05-1.8, 0.125-0.78, and 0.25-0.37 ml/min) and linearly through most of their course. Doubling the volume of 0.125 g/ml-glucose meal did not change the rate of emptying. Converting grams of glucose to their caloric content, the emptying rate in kcal/min becomes constant (approx 0.4 kcal/min) in this range of concentrations. Isocaloric casein hydrolysate and medium-chain triglyceride oil meals at 0.5 kcal/ml empty at the same rate as glucose. The precision of this regulation is sufficient to give it a role in preabsorptive satiety and the control of caloric intake.

Original languageEnglish (US)
Pages (from-to)R254-R260
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume5
Issue number3
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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