Calorie Restriction in Overweight Seniors: Response of Older Adults to a Dieting Study: The CROSSROADS Randomized Controlled Clinical Trial

Marilyn C. Haas, Eric V. Bodner, Cynthia J. Brown, David Bryan, David R. Buys, Akilah Dulin Keita, Lee Anne Flagg, Amy Goss, Barbara Gower, Martha Hovater, Gary Hunter, Christine S. Ritchie, David L. Roth, Brooks C. Wingo, Jamy Ard, Julie L. Locher

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a study designed to evaluate whether the benefits of intentional weight loss exceed the potential risks in a group of community-dwelling obese older adults who were at increased risk for cardiometabolic disease. The CROSSROADS trial used a prospective randomized controlled design to compare the effects of changes in diet composition alone or combined with weight loss with an exercise only control intervention on body composition and adipose tissue deposition (Specific Aim #1: To compare the effects of changes in diet composition alone or combined with weight loss with an exercise only control intervention on body composition, namely visceral adipose tissue), cardiometabolic disease risk (Specific Aim #2: To compare the effects of a change in diet composition alone or combined with weight loss with an exercise only control intervention on cardiometabolic disease risk), and functional status and quality of life (Specific Aim #3: To compare the effects of a change in diet composition alone or combined with weight loss with an exercise only control intervention on functional status and quality of life). Participants were randomly assigned to one of three groups: Exercise Only (Control) Intervention, Exercise + Diet Quality + Weight Maintenance Intervention, or Exercise + Diet Quality + Weight Loss Intervention. CROSSROADS utilized a lifestyle intervention approach consisting of exercise, dietary, and behavioral components. The development and implementation of the CROSSROADS protocol, including a description of the methodology, detailing specific elements of the lifestyle intervention, assurances of treatment fidelity, and participant retention; outcome measures and adverse event monitoring; as well as unique data management features of the trial results, are presented in this article.

Original languageEnglish (US)
Pages (from-to)376-400
Number of pages25
JournalJournal of Nutrition in Gerontology and Geriatrics
Volume33
Issue number4
DOIs
StatePublished - Oct 2 2014

Keywords

  • dietary intervention
  • lifestyle intervention
  • obesity
  • older adults
  • randomized controlled trial
  • weight loss

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Geriatrics and Gerontology

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