TY - JOUR
T1 - Calorie Restriction in Overweight Seniors
T2 - Response of Older Adults to a Dieting Study: The CROSSROADS Randomized Controlled Clinical Trial
AU - Haas, Marilyn C.
AU - Bodner, Eric V.
AU - Brown, Cynthia J.
AU - Bryan, David
AU - Buys, David R.
AU - Keita, Akilah Dulin
AU - Flagg, Lee Anne
AU - Goss, Amy
AU - Gower, Barbara
AU - Hovater, Martha
AU - Hunter, Gary
AU - Ritchie, Christine S.
AU - Roth, David L.
AU - Wingo, Brooks C.
AU - Ard, Jamy
AU - Locher, Julie L.
N1 - Funding Information:
This work was supported by the National Institute on Aging (R01AG033094; K07AG043588), the National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056336, P60DK079626, T32DK062710, R00DK83333), the National Heart, Lung, and Blood Institute (T32HL105349), the National Center for Advancing Translational Sciences (UL1RR025777), and the Agency for Healthcare Research and Quality (T32HS013852).
Publisher Copyright:
© 2014,Taylor & Francis Group, LLC.
PY - 2014/10/2
Y1 - 2014/10/2
N2 - We conducted a study designed to evaluate whether the benefits of intentional weight loss exceed the potential risks in a group of community-dwelling obese older adults who were at increased risk for cardiometabolic disease. The CROSSROADS trial used a prospective randomized controlled design to compare the effects of changes in diet composition alone or combined with weight loss with an exercise only control intervention on body composition and adipose tissue deposition (Specific Aim #1: To compare the effects of changes in diet composition alone or combined with weight loss with an exercise only control intervention on body composition, namely visceral adipose tissue), cardiometabolic disease risk (Specific Aim #2: To compare the effects of a change in diet composition alone or combined with weight loss with an exercise only control intervention on cardiometabolic disease risk), and functional status and quality of life (Specific Aim #3: To compare the effects of a change in diet composition alone or combined with weight loss with an exercise only control intervention on functional status and quality of life). Participants were randomly assigned to one of three groups: Exercise Only (Control) Intervention, Exercise + Diet Quality + Weight Maintenance Intervention, or Exercise + Diet Quality + Weight Loss Intervention. CROSSROADS utilized a lifestyle intervention approach consisting of exercise, dietary, and behavioral components. The development and implementation of the CROSSROADS protocol, including a description of the methodology, detailing specific elements of the lifestyle intervention, assurances of treatment fidelity, and participant retention; outcome measures and adverse event monitoring; as well as unique data management features of the trial results, are presented in this article.
AB - We conducted a study designed to evaluate whether the benefits of intentional weight loss exceed the potential risks in a group of community-dwelling obese older adults who were at increased risk for cardiometabolic disease. The CROSSROADS trial used a prospective randomized controlled design to compare the effects of changes in diet composition alone or combined with weight loss with an exercise only control intervention on body composition and adipose tissue deposition (Specific Aim #1: To compare the effects of changes in diet composition alone or combined with weight loss with an exercise only control intervention on body composition, namely visceral adipose tissue), cardiometabolic disease risk (Specific Aim #2: To compare the effects of a change in diet composition alone or combined with weight loss with an exercise only control intervention on cardiometabolic disease risk), and functional status and quality of life (Specific Aim #3: To compare the effects of a change in diet composition alone or combined with weight loss with an exercise only control intervention on functional status and quality of life). Participants were randomly assigned to one of three groups: Exercise Only (Control) Intervention, Exercise + Diet Quality + Weight Maintenance Intervention, or Exercise + Diet Quality + Weight Loss Intervention. CROSSROADS utilized a lifestyle intervention approach consisting of exercise, dietary, and behavioral components. The development and implementation of the CROSSROADS protocol, including a description of the methodology, detailing specific elements of the lifestyle intervention, assurances of treatment fidelity, and participant retention; outcome measures and adverse event monitoring; as well as unique data management features of the trial results, are presented in this article.
KW - dietary intervention
KW - lifestyle intervention
KW - obesity
KW - older adults
KW - randomized controlled trial
KW - weight loss
UR - http://www.scopus.com/inward/record.url?scp=84912065393&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84912065393&partnerID=8YFLogxK
U2 - 10.1080/21551197.2014.965993
DO - 10.1080/21551197.2014.965993
M3 - Article
C2 - 25424512
AN - SCOPUS:84912065393
SN - 2155-1197
VL - 33
SP - 376
EP - 400
JO - Journal of Nutrition in Gerontology and Geriatrics
JF - Journal of Nutrition in Gerontology and Geriatrics
IS - 4
ER -