Caloric restriction: Impact upon pituitary function and reproduction

Bronwen Martin, Erin Golden, Olga D. Carlson, Josephine M. Egan, Mark P. Mattson, Stuart Maudsley

Research output: Contribution to journalArticle

Abstract

Reduced energy intake, or caloric restriction (CR), is known to extend life span and to retard age-related health decline in a number of different species, including worms, flies, fish, mice and rats. CR has been shown to reduce oxidative stress, improve insulin sensitivity, and alter neuroendocrine responses and central nervous system (CNS) function in animals. CR has particularly profound and complex actions upon reproductive health. At the reductionist level the most crucial physiological function of any organism is its capacity to reproduce. For a successful species to thrive, the balance between available energy (food) and the energy expenditure required for reproduction must be tightly linked. An ability to coordinate energy balance and fecundity involves complex interactions of hormones from both the periphery and the CNS and primarily centers upon the master endocrine gland, the anterior pituitary. In this review article we review the effects of CR on pituitary gonadotrope function and on the male and female reproductive axes. A better understanding of how dietary energy intake affects reproductive axis function and endocrine pulsatility could provide novel strategies for the prevention and management of reproductive dysfunction and its associated comorbidities.

Original languageEnglish (US)
Pages (from-to)209-224
Number of pages16
JournalAgeing Research Reviews
Volume7
Issue number3
DOIs
StatePublished - Oct 2008

Fingerprint

Caloric Restriction
Reproduction
Neurology
Energy Intake
Central Nervous System
Health
Endocrine Glands
Oxidative stress
Reproductive Health
Energy balance
Diptera
Fish
Energy Metabolism
Fertility
Insulin Resistance
Comorbidity
Rats
Fishes
Animals
Oxidative Stress

Keywords

  • Caloric restriction
  • Neuroendocrine pulsatility
  • Pituitary

ASJC Scopus subject areas

  • Aging
  • Biochemistry

Cite this

Martin, B., Golden, E., Carlson, O. D., Egan, J. M., Mattson, M. P., & Maudsley, S. (2008). Caloric restriction: Impact upon pituitary function and reproduction. Ageing Research Reviews, 7(3), 209-224. https://doi.org/10.1016/j.arr.2008.01.002

Caloric restriction : Impact upon pituitary function and reproduction. / Martin, Bronwen; Golden, Erin; Carlson, Olga D.; Egan, Josephine M.; Mattson, Mark P.; Maudsley, Stuart.

In: Ageing Research Reviews, Vol. 7, No. 3, 10.2008, p. 209-224.

Research output: Contribution to journalArticle

Martin, B, Golden, E, Carlson, OD, Egan, JM, Mattson, MP & Maudsley, S 2008, 'Caloric restriction: Impact upon pituitary function and reproduction', Ageing Research Reviews, vol. 7, no. 3, pp. 209-224. https://doi.org/10.1016/j.arr.2008.01.002
Martin B, Golden E, Carlson OD, Egan JM, Mattson MP, Maudsley S. Caloric restriction: Impact upon pituitary function and reproduction. Ageing Research Reviews. 2008 Oct;7(3):209-224. https://doi.org/10.1016/j.arr.2008.01.002
Martin, Bronwen ; Golden, Erin ; Carlson, Olga D. ; Egan, Josephine M. ; Mattson, Mark P. ; Maudsley, Stuart. / Caloric restriction : Impact upon pituitary function and reproduction. In: Ageing Research Reviews. 2008 ; Vol. 7, No. 3. pp. 209-224.
@article{a6fca77352344966b8288886e9f58bef,
title = "Caloric restriction: Impact upon pituitary function and reproduction",
abstract = "Reduced energy intake, or caloric restriction (CR), is known to extend life span and to retard age-related health decline in a number of different species, including worms, flies, fish, mice and rats. CR has been shown to reduce oxidative stress, improve insulin sensitivity, and alter neuroendocrine responses and central nervous system (CNS) function in animals. CR has particularly profound and complex actions upon reproductive health. At the reductionist level the most crucial physiological function of any organism is its capacity to reproduce. For a successful species to thrive, the balance between available energy (food) and the energy expenditure required for reproduction must be tightly linked. An ability to coordinate energy balance and fecundity involves complex interactions of hormones from both the periphery and the CNS and primarily centers upon the master endocrine gland, the anterior pituitary. In this review article we review the effects of CR on pituitary gonadotrope function and on the male and female reproductive axes. A better understanding of how dietary energy intake affects reproductive axis function and endocrine pulsatility could provide novel strategies for the prevention and management of reproductive dysfunction and its associated comorbidities.",
keywords = "Caloric restriction, Neuroendocrine pulsatility, Pituitary",
author = "Bronwen Martin and Erin Golden and Carlson, {Olga D.} and Egan, {Josephine M.} and Mattson, {Mark P.} and Stuart Maudsley",
year = "2008",
month = "10",
doi = "10.1016/j.arr.2008.01.002",
language = "English (US)",
volume = "7",
pages = "209--224",
journal = "Ageing Research Reviews",
issn = "1568-1637",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Caloric restriction

T2 - Impact upon pituitary function and reproduction

AU - Martin, Bronwen

AU - Golden, Erin

AU - Carlson, Olga D.

AU - Egan, Josephine M.

AU - Mattson, Mark P.

AU - Maudsley, Stuart

PY - 2008/10

Y1 - 2008/10

N2 - Reduced energy intake, or caloric restriction (CR), is known to extend life span and to retard age-related health decline in a number of different species, including worms, flies, fish, mice and rats. CR has been shown to reduce oxidative stress, improve insulin sensitivity, and alter neuroendocrine responses and central nervous system (CNS) function in animals. CR has particularly profound and complex actions upon reproductive health. At the reductionist level the most crucial physiological function of any organism is its capacity to reproduce. For a successful species to thrive, the balance between available energy (food) and the energy expenditure required for reproduction must be tightly linked. An ability to coordinate energy balance and fecundity involves complex interactions of hormones from both the periphery and the CNS and primarily centers upon the master endocrine gland, the anterior pituitary. In this review article we review the effects of CR on pituitary gonadotrope function and on the male and female reproductive axes. A better understanding of how dietary energy intake affects reproductive axis function and endocrine pulsatility could provide novel strategies for the prevention and management of reproductive dysfunction and its associated comorbidities.

AB - Reduced energy intake, or caloric restriction (CR), is known to extend life span and to retard age-related health decline in a number of different species, including worms, flies, fish, mice and rats. CR has been shown to reduce oxidative stress, improve insulin sensitivity, and alter neuroendocrine responses and central nervous system (CNS) function in animals. CR has particularly profound and complex actions upon reproductive health. At the reductionist level the most crucial physiological function of any organism is its capacity to reproduce. For a successful species to thrive, the balance between available energy (food) and the energy expenditure required for reproduction must be tightly linked. An ability to coordinate energy balance and fecundity involves complex interactions of hormones from both the periphery and the CNS and primarily centers upon the master endocrine gland, the anterior pituitary. In this review article we review the effects of CR on pituitary gonadotrope function and on the male and female reproductive axes. A better understanding of how dietary energy intake affects reproductive axis function and endocrine pulsatility could provide novel strategies for the prevention and management of reproductive dysfunction and its associated comorbidities.

KW - Caloric restriction

KW - Neuroendocrine pulsatility

KW - Pituitary

UR - http://www.scopus.com/inward/record.url?scp=51649113431&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51649113431&partnerID=8YFLogxK

U2 - 10.1016/j.arr.2008.01.002

DO - 10.1016/j.arr.2008.01.002

M3 - Article

C2 - 18329344

AN - SCOPUS:51649113431

VL - 7

SP - 209

EP - 224

JO - Ageing Research Reviews

JF - Ageing Research Reviews

SN - 1568-1637

IS - 3

ER -