TY - JOUR
T1 - Caloric restriction and intermittent fasting
T2 - Two potential diets for successful brain aging
AU - Martin, Bronwen
AU - Mattson, Mark P.
AU - Maudsley, Stuart
PY - 2006/8
Y1 - 2006/8
N2 - The vulnerability of the nervous system to advancing age is all too often manifest in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. In this review article we describe evidence suggesting that two dietary interventions, caloric restriction (CR) and intermittent fasting (IF), can prolong the health-span of the nervous system by impinging upon fundamental metabolic and cellular signaling pathways that regulate life-span. CR and IF affect energy and oxygen radical metabolism, and cellular stress response systems, in ways that protect neurons against genetic and environmental factors to which they would otherwise succumb during aging. There are multiple interactive pathways and molecular mechanisms by which CR and IF benefit neurons including those involving insulin-like signaling, FoxO transcription factors, sirtuins and peroxisome proliferator-activated receptors. These pathways stimulate the production of protein chaperones, neurotrophic factors and antioxidant enzymes, all of which help cells cope with stress and resist disease. A better understanding of the impact of CR and IF on the aging nervous system will likely lead to novel approaches for preventing and treating neurodegenerative disorders.
AB - The vulnerability of the nervous system to advancing age is all too often manifest in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. In this review article we describe evidence suggesting that two dietary interventions, caloric restriction (CR) and intermittent fasting (IF), can prolong the health-span of the nervous system by impinging upon fundamental metabolic and cellular signaling pathways that regulate life-span. CR and IF affect energy and oxygen radical metabolism, and cellular stress response systems, in ways that protect neurons against genetic and environmental factors to which they would otherwise succumb during aging. There are multiple interactive pathways and molecular mechanisms by which CR and IF benefit neurons including those involving insulin-like signaling, FoxO transcription factors, sirtuins and peroxisome proliferator-activated receptors. These pathways stimulate the production of protein chaperones, neurotrophic factors and antioxidant enzymes, all of which help cells cope with stress and resist disease. A better understanding of the impact of CR and IF on the aging nervous system will likely lead to novel approaches for preventing and treating neurodegenerative disorders.
KW - Aging
KW - Caloric restriction
KW - Intermittent fasting
UR - http://www.scopus.com/inward/record.url?scp=33748540014&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748540014&partnerID=8YFLogxK
U2 - 10.1016/j.arr.2006.04.002
DO - 10.1016/j.arr.2006.04.002
M3 - Article
C2 - 16899414
AN - SCOPUS:33748540014
SN - 1568-1637
VL - 5
SP - 332
EP - 353
JO - Ageing Research Reviews
JF - Ageing Research Reviews
IS - 3
ER -