Caloric restriction and intermittent fasting

Two potential diets for successful brain aging

Bronwen Martin, Mark P. Mattson, Stuart Maudsley

Research output: Contribution to journalArticle

Abstract

The vulnerability of the nervous system to advancing age is all too often manifest in neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. In this review article we describe evidence suggesting that two dietary interventions, caloric restriction (CR) and intermittent fasting (IF), can prolong the health-span of the nervous system by impinging upon fundamental metabolic and cellular signaling pathways that regulate life-span. CR and IF affect energy and oxygen radical metabolism, and cellular stress response systems, in ways that protect neurons against genetic and environmental factors to which they would otherwise succumb during aging. There are multiple interactive pathways and molecular mechanisms by which CR and IF benefit neurons including those involving insulin-like signaling, FoxO transcription factors, sirtuins and peroxisome proliferator-activated receptors. These pathways stimulate the production of protein chaperones, neurotrophic factors and antioxidant enzymes, all of which help cells cope with stress and resist disease. A better understanding of the impact of CR and IF on the aging nervous system will likely lead to novel approaches for preventing and treating neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)332-353
Number of pages22
JournalAgeing Research Reviews
Volume5
Issue number3
DOIs
StatePublished - Aug 2006

Fingerprint

Caloric Restriction
Nutrition
Fasting
Brain
Neurology
Aging of materials
Nervous System
Diet
Neurodegenerative Diseases
Neurons
Sirtuins
Cell signaling
Peroxisome Proliferator-Activated Receptors
Nerve Growth Factors
Metabolism
Parkinson Disease
Reactive Oxygen Species
Alzheimer Disease
Transcription Factors
Antioxidants

Keywords

  • Aging
  • Caloric restriction
  • Intermittent fasting

ASJC Scopus subject areas

  • Aging
  • Biochemistry

Cite this

Caloric restriction and intermittent fasting : Two potential diets for successful brain aging. / Martin, Bronwen; Mattson, Mark P.; Maudsley, Stuart.

In: Ageing Research Reviews, Vol. 5, No. 3, 08.2006, p. 332-353.

Research output: Contribution to journalArticle

Martin, Bronwen ; Mattson, Mark P. ; Maudsley, Stuart. / Caloric restriction and intermittent fasting : Two potential diets for successful brain aging. In: Ageing Research Reviews. 2006 ; Vol. 5, No. 3. pp. 332-353.
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