Calmodulin regulation (calmodulation) of voltage-gated calcium channels

Manu Ben-Johny, David T. Yue

Research output: Contribution to journalReview article

Abstract

Calmodulin regulation (calmodulation) of the family of voltage-gated CaV1-2 channels comprises a prominent prototype for ion channel regulation, remarkable for its powerful Ca2+ sensing capabilities, deep in elegant mechanistic lessons, and rich in biological and therapeutic implications. This field thereby resides squarely at the epicenter of Ca2+ signaling biology, ion channel biophysics, and therapeutic advance. This review summarizes the historical development of ideas in this field, the scope and richly patterned organization of Ca2+ feedback behaviors encompassed by this system, and the long-standing challenges and recent developments in discerning a molecular basis for calmodulation. We conclude by highlighting the considerable synergy between mechanism, biological insight, and promising therapeutics.

Original languageEnglish (US)
Pages (from-to)679-692
Number of pages14
JournalJournal of General Physiology
Volume143
Issue number6
DOIs
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Physiology

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