Calmodulin kinase signaling in heart: An intriguing candidate target for therapy of myocardial dysfunction and arrhythmias

Research output: Contribution to journalArticle

Abstract

The multifunctional Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) has emerged as a proarrhythmic and procardiomyopathic signal in a wide range of structural heart diseases. This review discusses CaMKII structure and function and recent evidence implicating CaMKII inhibition as a potential strategy for treating myocardial dysfunction and arrhythmias in the setting of structural heart disease.

Original languageEnglish (US)
Pages (from-to)39-55
Number of pages17
JournalPharmacology and Therapeutics
Volume106
Issue number1
DOIs
StatePublished - Apr 2005
Externally publishedYes

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Calcium-Calmodulin-Dependent Protein Kinases
Protein Kinases
Cardiac Arrhythmias
Heart Diseases
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Therapeutics

Keywords

  • Arrhythmia
  • Calmodulin kinase
  • Cellular calcium
  • Electrophysiology
  • Structural heart disease
  • Sudden death

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "The multifunctional Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) has emerged as a proarrhythmic and procardiomyopathic signal in a wide range of structural heart diseases. This review discusses CaMKII structure and function and recent evidence implicating CaMKII inhibition as a potential strategy for treating myocardial dysfunction and arrhythmias in the setting of structural heart disease.",
keywords = "Arrhythmia, Calmodulin kinase, Cellular calcium, Electrophysiology, Structural heart disease, Sudden death",
author = "Mark Anderson",
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KW - Sudden death

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