Calmodulin and the philosopher's stone: Changing Ca2+ into arrhythmias

Research output: Contribution to journalShort survey

Abstract

It has been recognized for some time that intracellular Ca2+ ([Ca2+]i) can contribute to the genesis of cardiac arrhythmias, but understanding of the molecular signaling machinery that links disordered [Ca2+]i to arrhythmias has been lacking. Exciting recent work has focused on the ubiquitous intracellular Ca2+-binding protein calmodulin. Calmodulin is a molecular sensor that can translate increases in [Ca2+]i into modulatory signals for ion channels and activate other Ca2+-dependent signaling molecules. This article will examine the implications of these recent findings for arrhythmogenesis and the development of new antiarrhythmic therapies.

Original languageEnglish (US)
Pages (from-to)195-197
Number of pages3
JournalJournal of cardiovascular electrophysiology
Volume13
Issue number2
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

    Fingerprint

Keywords

  • Afterdepolarizations
  • Calmodulin kinase
  • Cardiomyopathy
  • L-type calcium current
  • Transient inward current

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this