CALM, A clathrin assembly protein, influences cell surface GluR2 abundance

Asaff Harel; Mark P. Mattson; Pamela J. Yao

doi:10.1007/s12017-010-8142-6

CALM, A clathrin assembly protein, influences cell surface GluR2 abundance

Asaff Harel, Mark P. Mattson, Pamela J. Yao

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The clathrin assembly protein, CALM, promotes the assembly of clathrin-coated vesicles. In a previous study, we showed that CALM controls the level of the synaptic vesicle protein VAMP2 at the plasma membrane by regulating VAMP2 endocytosis. Here, we provide evidence that CALM also influences the cell surface level of the AMPA receptor subunit GluR2. Although mechanistic details as well as the physiological relevance of CALM and GluR2 in the neuron have yet to be established, CALM-mediated trafficking could function as a component of a dedicated system for controlling postsynaptic abundance of GluR2.

Original language	English (US)
Pages (from-to)	88-90
Number of pages	3
Journal	NeuroMolecular Medicine
Volume	13
Issue number	1
DOIs	https://doi.org/10.1007/s12017-010-8142-6
State	Published - Mar 2011
Externally published	Yes

Keywords

AMPA receptor
AP180
Bungarotoxin binding site
CALM
Clathrin
GluR2

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Molecular Medicine
Neurology

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10.1007/s12017-010-8142-6

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abstract = "The clathrin assembly protein, CALM, promotes the assembly of clathrin-coated vesicles. In a previous study, we showed that CALM controls the level of the synaptic vesicle protein VAMP2 at the plasma membrane by regulating VAMP2 endocytosis. Here, we provide evidence that CALM also influences the cell surface level of the AMPA receptor subunit GluR2. Although mechanistic details as well as the physiological relevance of CALM and GluR2 in the neuron have yet to be established, CALM-mediated trafficking could function as a component of a dedicated system for controlling postsynaptic abundance of GluR2.",

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AU - Harel, Asaff

AU - Mattson, Mark P.

AU - Yao, Pamela J.

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AB - The clathrin assembly protein, CALM, promotes the assembly of clathrin-coated vesicles. In a previous study, we showed that CALM controls the level of the synaptic vesicle protein VAMP2 at the plasma membrane by regulating VAMP2 endocytosis. Here, we provide evidence that CALM also influences the cell surface level of the AMPA receptor subunit GluR2. Although mechanistic details as well as the physiological relevance of CALM and GluR2 in the neuron have yet to be established, CALM-mediated trafficking could function as a component of a dedicated system for controlling postsynaptic abundance of GluR2.

KW - AMPA receptor

KW - AP180

KW - Bungarotoxin binding site

KW - CALM

KW - Clathrin

KW - GluR2

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CALM, A clathrin assembly protein, influences cell surface GluR2 abundance

Abstract

Keywords

ASJC Scopus subject areas

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