Calibrated MRI to evaluate cerebral hemodynamics in patients with an internal carotid artery occlusion

Jill B. De Vis, Esben T. Petersen, Alex Bhogal, Nolan S. Hartkamp, Catharina J.M. Klijn, L. J. Kappelle, J. Hendrikse

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to assess whether calibrated magnetic resonance imaging (MRI) can identify regional variances in cerebral hemodynamics caused by vascular disease. For this, arterial spin labeling (ASL)/blood oxygen level-dependent (BOLD) MRI was performed in 11 patients (65±7 years) and 14 controls (66±4 years). Cerebral blood flow (CBF), ASL cerebrovascular reactivity (CVR), BOLD CVR, oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO 2) were evaluated. The CBF was 34±5 and 36±11 mL/100 g per minute in the ipsilateral middle cerebral artery (MCA) territory of the patients and the controls. Arterial spin labeling CVR was 44±20 and 53±10% per 10 mm Hg EtCO 2 in patients and controls. The BOLD CVR was lower in the patients compared with the controls (1.3±0.8 versus 2.2±0.4% per 10 mm Hg EtCO 2, P<0.01). The OEF was 41±8% and 38±6%, and the CMRO 2 was 116±39 and 111±40 μmol/100 g per minute in the patients and the controls. The BOLD CVR was lower in the ipsilateral than in the contralateral MCA territory of the patients (1.2±0.6 versus 1.6±0.5% per 10 mmHg EtCO 2, P<0.01). Analysis was hampered in three patients due to delayed arrival time. Thus, regional hemodynamic impairment was identified with calibrated MRI. Delayed arrival artifacts limited the interpretation of the images in some patients.

Original languageEnglish (US)
Pages (from-to)1015-1023
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2015

Keywords

  • calibrated MRI
  • cerebral metabolic rate of oxygen
  • cerebrovascular reactivity
  • internal carotid artery
  • occlusion
  • oxygen extraction fraction

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    De Vis, J. B., Petersen, E. T., Bhogal, A., Hartkamp, N. S., Klijn, C. J. M., Kappelle, L. J., & Hendrikse, J. (2015). Calibrated MRI to evaluate cerebral hemodynamics in patients with an internal carotid artery occlusion. Journal of Cerebral Blood Flow and Metabolism, 35(6), 1015-1023. https://doi.org/10.1038/jcbfm.2015.14