Calculation of the biological effective dose for piecewise defined dose-rate fits

Research output: Contribution to journalArticlepeer-review

Abstract

An algorithmic solution to the biological effective dose (BED) calculation from the Lea-Catcheside formula for a piecewise defined function is presented. Data from patients treated for metastatic thyroid cancer were used to illustrate the solution. The Lea-Catcheside formula for the G -factor of the BED is integrated numerically using a large number of small trapezoidal fits to each integral. The algorithmically calculated BED is compatible with an analytic calculation for a similarly valued exponentially fitted dose-rate plot and is the only resolution for piecewise defined dose-rate functions.

Original languageEnglish (US)
Pages (from-to)904-907
Number of pages4
JournalMedical physics
Volume36
Issue number3
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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