Calculation of entrophy changes in biological processes: Folding, finding, and oligomerization

Research output: Contribution to journalArticle

Abstract

Changes in configurational entropy represent one of the major contributions to the thermodynamics of folding, binding, and oligomerization. Methods have been developed to estimate changes in the entropy of the backbone and side chains, and for the loss of translational entropy. These methods have been used in combination with empirical methods that provide estimates of the changes in entropy of solvation as well as estimates of the changes of enthalpy. The results of such calculations are in excellent agreement with experimentally observed values.

Original languageEnglish (US)
Pages (from-to)167-177
Number of pages11
JournalMethods in enzymology
Volume323
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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