TY - JOUR
T1 - Calculation of a gallbladder ejection fraction
T2 - Advantage of continuous sincalide infusion over the three-minute infusion method
AU - Ziessman, H. A.
AU - Fahey, F. H.
AU - Hixson, D. J.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The purpose of this study was to investigate alternative methods of infusing sincalide for calculation of a gallbladder ejection fraction (GBEF) during cholescintigraphy (5 mCi 99mTc-mebrofenin). After gallbladder filling, three methods of infusion were compared in 23 normal volunteers: (1) 0.02 μg/kg as a 3-min infusion, (2) 0.02 μg/kg as a 30-min infusion, and (3) 0.01 μg/kg as a 30-min infusion (14 subjects), all performed on separate days. With the 3-min infusion, the emptying pattern was usually exponential and completed in 15 min. The mean (GBEF) was 52% ± 26% at 20 min and 56% ± 27% at 30 min (range 0%-100%). GBEFs were less than 35% in six subjects and 35%-38% in four. Side effects were noted by 11/23 subjects. With the slow infusions, emptying was linear; no side effects were noted. With 0.02 μg/kg, the mean GBEF was 50% ± 27% at 20 min and 70% ± 22% at 30 min (range 26%- 95%). Similar results were seen with 0.01 μg/kg, but the data were more limited. The 30-min infusion had a higher normalcy rate than the 3-min method (91% versus 74%). Females had significantly lower GBEFs than males (p < 0.05%). We conclude that the slow infusion method is preferable; it is more physiological, results in more complete emptying, has no side effects, has less normal variability, and should improve the specificity of this test. The lower mean female GBEF may have pathophysiological significance.
AB - The purpose of this study was to investigate alternative methods of infusing sincalide for calculation of a gallbladder ejection fraction (GBEF) during cholescintigraphy (5 mCi 99mTc-mebrofenin). After gallbladder filling, three methods of infusion were compared in 23 normal volunteers: (1) 0.02 μg/kg as a 3-min infusion, (2) 0.02 μg/kg as a 30-min infusion, and (3) 0.01 μg/kg as a 30-min infusion (14 subjects), all performed on separate days. With the 3-min infusion, the emptying pattern was usually exponential and completed in 15 min. The mean (GBEF) was 52% ± 26% at 20 min and 56% ± 27% at 30 min (range 0%-100%). GBEFs were less than 35% in six subjects and 35%-38% in four. Side effects were noted by 11/23 subjects. With the slow infusions, emptying was linear; no side effects were noted. With 0.02 μg/kg, the mean GBEF was 50% ± 27% at 20 min and 70% ± 22% at 30 min (range 26%- 95%). Similar results were seen with 0.01 μg/kg, but the data were more limited. The 30-min infusion had a higher normalcy rate than the 3-min method (91% versus 74%). Females had significantly lower GBEFs than males (p < 0.05%). We conclude that the slow infusion method is preferable; it is more physiological, results in more complete emptying, has no side effects, has less normal variability, and should improve the specificity of this test. The lower mean female GBEF may have pathophysiological significance.
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M3 - Article
C2 - 1552338
AN - SCOPUS:0026519432
VL - 33
SP - 537
EP - 541
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 4
ER -