Calcium-sensitive inactivation in the gating of single calcium channels

David T. Yue, Peter H. Backx, John P. Imredy

Research output: Contribution to journalArticle

Abstract

Voltage-activated calcium channels open and close, or gate, according to molecular transition rates that are regulated by transmembrane voltage and neurotransmitters. Here evidence for the control of gating by calcium was found in electrophysiological records of single, L-type calcium channels in heart cells. Conditional open probability analysis revealed that calcium entry during the opening of a single channel produces alterations in gating transition rates that evolve over the course of hundreds of milliseconds. Such alteration of calcium-channel gating by entry of a favored permeant ion provides a mechanism for the short-term modulation of single-ion channels.

Original languageEnglish (US)
Pages (from-to)1735-1738
Number of pages4
JournalScience
Volume250
Issue number4988
StatePublished - Dec 21 1990

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Calcium Channels
Calcium
L-Type Calcium Channels
Ion Channels
Neurotransmitter Agents
Ions

ASJC Scopus subject areas

  • General

Cite this

Yue, D. T., Backx, P. H., & Imredy, J. P. (1990). Calcium-sensitive inactivation in the gating of single calcium channels. Science, 250(4988), 1735-1738.

Calcium-sensitive inactivation in the gating of single calcium channels. / Yue, David T.; Backx, Peter H.; Imredy, John P.

In: Science, Vol. 250, No. 4988, 21.12.1990, p. 1735-1738.

Research output: Contribution to journalArticle

Yue, DT, Backx, PH & Imredy, JP 1990, 'Calcium-sensitive inactivation in the gating of single calcium channels', Science, vol. 250, no. 4988, pp. 1735-1738.
Yue DT, Backx PH, Imredy JP. Calcium-sensitive inactivation in the gating of single calcium channels. Science. 1990 Dec 21;250(4988):1735-1738.
Yue, David T. ; Backx, Peter H. ; Imredy, John P. / Calcium-sensitive inactivation in the gating of single calcium channels. In: Science. 1990 ; Vol. 250, No. 4988. pp. 1735-1738.
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