Calcium phosphate mineralized GBR membranes: Preparation and properties

A. H K Chou, R. Z. LeGeros, D. Mijares, C. Frondoza, J. P. LeGeros

Research output: Contribution to journalArticle

Abstract

The osteoconductive property of calcium phosphate (CaP) biomaterials allow attachment, proliferation, migration, and phenotypic expression of bone cells leading to formation of new bone. The purpose of research is to develop new method of mineralizing commercial GBR membranes with calcium phosphate (CaP) and determine cell response. Resolut Adapt LT (Gore-tex) composed of co-polymer PGA/TMC and Biomend Extend (Zimmer) composed of bovine collagen were used. Membranes were mineralized with CaP using precipitation and new microwave methods. The mineralized and non-mineralized membranes were characterized using SEM, EDS, XRD, FT-IR, and TGA. Cell response to mineralized and non-mineralized membranes was determined using human osteoblast-like cells (MG-63). Microwave method was more efficient in terms of amount of minerals incorporated with membranes and time required. SEM, EDS, and FT-IR identified carbonate apatite in the mineralized membranes. No significant difference in cell proliferation was observed between mineralized and non-mineralized membranes. Greater production of type 1 collagen was observed with CaP mineralized membranes.

Original languageEnglish (US)
Pages (from-to)435-438
Number of pages4
JournalKey Engineering Materials
Volume361-363 I
StatePublished - 2008

Fingerprint

Calcium phosphate
Membranes
Collagen
Energy dispersive spectroscopy
Bone
Microwaves
Prostaglandins A
Scanning electron microscopy
calcium phosphate
Osteoblasts
Apatite
Cell proliferation
Biocompatible Materials
Collagen Type I
Biomaterials
Minerals
Carbonates
Polymers

Keywords

  • Calcium phosphate
  • Carbonate apatite
  • Guided bone regeneration

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Chou, A. H. K., LeGeros, R. Z., Mijares, D., Frondoza, C., & LeGeros, J. P. (2008). Calcium phosphate mineralized GBR membranes: Preparation and properties. Key Engineering Materials, 361-363 I, 435-438.

Calcium phosphate mineralized GBR membranes : Preparation and properties. / Chou, A. H K; LeGeros, R. Z.; Mijares, D.; Frondoza, C.; LeGeros, J. P.

In: Key Engineering Materials, Vol. 361-363 I, 2008, p. 435-438.

Research output: Contribution to journalArticle

Chou, AHK, LeGeros, RZ, Mijares, D, Frondoza, C & LeGeros, JP 2008, 'Calcium phosphate mineralized GBR membranes: Preparation and properties', Key Engineering Materials, vol. 361-363 I, pp. 435-438.
Chou AHK, LeGeros RZ, Mijares D, Frondoza C, LeGeros JP. Calcium phosphate mineralized GBR membranes: Preparation and properties. Key Engineering Materials. 2008;361-363 I:435-438.
Chou, A. H K ; LeGeros, R. Z. ; Mijares, D. ; Frondoza, C. ; LeGeros, J. P. / Calcium phosphate mineralized GBR membranes : Preparation and properties. In: Key Engineering Materials. 2008 ; Vol. 361-363 I. pp. 435-438.
@article{da389db2d77e4427934304d6a050f454,
title = "Calcium phosphate mineralized GBR membranes: Preparation and properties",
abstract = "The osteoconductive property of calcium phosphate (CaP) biomaterials allow attachment, proliferation, migration, and phenotypic expression of bone cells leading to formation of new bone. The purpose of research is to develop new method of mineralizing commercial GBR membranes with calcium phosphate (CaP) and determine cell response. Resolut Adapt LT (Gore-tex) composed of co-polymer PGA/TMC and Biomend Extend (Zimmer) composed of bovine collagen were used. Membranes were mineralized with CaP using precipitation and new microwave methods. The mineralized and non-mineralized membranes were characterized using SEM, EDS, XRD, FT-IR, and TGA. Cell response to mineralized and non-mineralized membranes was determined using human osteoblast-like cells (MG-63). Microwave method was more efficient in terms of amount of minerals incorporated with membranes and time required. SEM, EDS, and FT-IR identified carbonate apatite in the mineralized membranes. No significant difference in cell proliferation was observed between mineralized and non-mineralized membranes. Greater production of type 1 collagen was observed with CaP mineralized membranes.",
keywords = "Calcium phosphate, Carbonate apatite, Guided bone regeneration",
author = "Chou, {A. H K} and LeGeros, {R. Z.} and D. Mijares and C. Frondoza and LeGeros, {J. P.}",
year = "2008",
language = "English (US)",
volume = "361-363 I",
pages = "435--438",
journal = "Key Engineering Materials",
issn = "1013-9826",
publisher = "Trans Tech Publications",

}

TY - JOUR

T1 - Calcium phosphate mineralized GBR membranes

T2 - Preparation and properties

AU - Chou, A. H K

AU - LeGeros, R. Z.

AU - Mijares, D.

AU - Frondoza, C.

AU - LeGeros, J. P.

PY - 2008

Y1 - 2008

N2 - The osteoconductive property of calcium phosphate (CaP) biomaterials allow attachment, proliferation, migration, and phenotypic expression of bone cells leading to formation of new bone. The purpose of research is to develop new method of mineralizing commercial GBR membranes with calcium phosphate (CaP) and determine cell response. Resolut Adapt LT (Gore-tex) composed of co-polymer PGA/TMC and Biomend Extend (Zimmer) composed of bovine collagen were used. Membranes were mineralized with CaP using precipitation and new microwave methods. The mineralized and non-mineralized membranes were characterized using SEM, EDS, XRD, FT-IR, and TGA. Cell response to mineralized and non-mineralized membranes was determined using human osteoblast-like cells (MG-63). Microwave method was more efficient in terms of amount of minerals incorporated with membranes and time required. SEM, EDS, and FT-IR identified carbonate apatite in the mineralized membranes. No significant difference in cell proliferation was observed between mineralized and non-mineralized membranes. Greater production of type 1 collagen was observed with CaP mineralized membranes.

AB - The osteoconductive property of calcium phosphate (CaP) biomaterials allow attachment, proliferation, migration, and phenotypic expression of bone cells leading to formation of new bone. The purpose of research is to develop new method of mineralizing commercial GBR membranes with calcium phosphate (CaP) and determine cell response. Resolut Adapt LT (Gore-tex) composed of co-polymer PGA/TMC and Biomend Extend (Zimmer) composed of bovine collagen were used. Membranes were mineralized with CaP using precipitation and new microwave methods. The mineralized and non-mineralized membranes were characterized using SEM, EDS, XRD, FT-IR, and TGA. Cell response to mineralized and non-mineralized membranes was determined using human osteoblast-like cells (MG-63). Microwave method was more efficient in terms of amount of minerals incorporated with membranes and time required. SEM, EDS, and FT-IR identified carbonate apatite in the mineralized membranes. No significant difference in cell proliferation was observed between mineralized and non-mineralized membranes. Greater production of type 1 collagen was observed with CaP mineralized membranes.

KW - Calcium phosphate

KW - Carbonate apatite

KW - Guided bone regeneration

UR - http://www.scopus.com/inward/record.url?scp=38149004915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149004915&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:38149004915

VL - 361-363 I

SP - 435

EP - 438

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -