CALCIUM OXALATE UROLITHIASIS IN THE RAT: IS IT A MODEL FOR HUMAN STONE DISEASE? A REVIEW OF RECENT LITERATURE.

S. R. Khan, R. L. Hackett

Research output: Contribution to journalArticlepeer-review

Abstract

Calcium oxalate stone disease is the most common human urinary stone disease in the Western Hemisphere. To understand different aspects of the disease, calcium oxalate urolithiasis in the rat is used as a model. Spontaneous calcium oxalate urolithiasis is very rare in rats. Thus the disease is experimentally induced and the rats are generally made hyperoxaluric either by administration of excess oxalate, exposure to the toxin ethylene glycol, or various nutritional manipulations. All the experimental models show renal injury associated with crystal deposition. Rat renal papillary tips and fornices appear to be the preferential sites for the deposition of large calcium oxalate calculi. Where urinary supersaturation of calcium oxalate has been studied the crystal forming rat urines are shown to have higher urinary supersaturation of calcium oxalate than their controls. Oxalate metabolism in the rat is nearly identical to that in humans.

Original languageEnglish (US)
Pages (from-to)759-774
Number of pages16
JournalScanning Electron Microscopy
Issue numberpt 2
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Control and Systems Engineering

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