Calcium-dependent chronotropic action of bovine parathyroid hormone (1-34) in isolated atria of Japanese quail, Coturnix coturnix japonica

James S.K. Sham; Peter K.T. Pang

doi:10.1016/0016-6480(86)90010-9

Calcium-dependent chronotropic action of bovine parathyroid hormone (1-34) in isolated atria of Japanese quail, Coturnix coturnix japonica

James S.K. Sham, Peter K.T. Pang

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The involvement of extracellular calcium in the chronotropic action of parathyroid hormone (PTH) in isolated quail atria was studied. Bovine (b) PTH-(1-34) caused dose-dependent increases in the atrial beating rate. The PTH-induced positive chronotropism was significantly attenuated by lowering the extracellular calcium concentration or by using the calcium channel antagonists verapamil and D600. This suggests the importance of calcium influx in the cardiac action of PTH. β-Adrenergic blockade with propranolol did not affect the responses to bPTH-(1-34). This further substantiates the previous findings that the PTH action is independent of cardiac β-adrenoceptor stimulation.

Original language	English (US)
Pages (from-to)	250-253
Number of pages	4
Journal	General and Comparative Endocrinology
Volume	64
Issue number	2
DOIs	https://doi.org/10.1016/0016-6480(86)90010-9
State	Published - Nov 1986

ASJC Scopus subject areas

Animal Science and Zoology
Endocrinology

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10.1016/0016-6480(86)90010-9

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title = "Calcium-dependent chronotropic action of bovine parathyroid hormone (1-34) in isolated atria of Japanese quail, Coturnix coturnix japonica",

abstract = "The involvement of extracellular calcium in the chronotropic action of parathyroid hormone (PTH) in isolated quail atria was studied. Bovine (b) PTH-(1-34) caused dose-dependent increases in the atrial beating rate. The PTH-induced positive chronotropism was significantly attenuated by lowering the extracellular calcium concentration or by using the calcium channel antagonists verapamil and D600. This suggests the importance of calcium influx in the cardiac action of PTH. β-Adrenergic blockade with propranolol did not affect the responses to bPTH-(1-34). This further substantiates the previous findings that the PTH action is independent of cardiac β-adrenoceptor stimulation.",

author = "Sham, {James S.K.} and Pang, {Peter K.T.}",

note = "Funding Information: This work was supported in part by NSF Grant PCM 81-05425 and NIH Grant lRO1 HL32879-01 to P. K. T. Pang.",

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AU - Sham, James S.K.

AU - Pang, Peter K.T.

N1 - Funding Information: This work was supported in part by NSF Grant PCM 81-05425 and NIH Grant lRO1 HL32879-01 to P. K. T. Pang.

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N2 - The involvement of extracellular calcium in the chronotropic action of parathyroid hormone (PTH) in isolated quail atria was studied. Bovine (b) PTH-(1-34) caused dose-dependent increases in the atrial beating rate. The PTH-induced positive chronotropism was significantly attenuated by lowering the extracellular calcium concentration or by using the calcium channel antagonists verapamil and D600. This suggests the importance of calcium influx in the cardiac action of PTH. β-Adrenergic blockade with propranolol did not affect the responses to bPTH-(1-34). This further substantiates the previous findings that the PTH action is independent of cardiac β-adrenoceptor stimulation.

AB - The involvement of extracellular calcium in the chronotropic action of parathyroid hormone (PTH) in isolated quail atria was studied. Bovine (b) PTH-(1-34) caused dose-dependent increases in the atrial beating rate. The PTH-induced positive chronotropism was significantly attenuated by lowering the extracellular calcium concentration or by using the calcium channel antagonists verapamil and D600. This suggests the importance of calcium influx in the cardiac action of PTH. β-Adrenergic blockade with propranolol did not affect the responses to bPTH-(1-34). This further substantiates the previous findings that the PTH action is independent of cardiac β-adrenoceptor stimulation.

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Calcium-dependent chronotropic action of bovine parathyroid hormone (1-34) in isolated atria of Japanese quail, Coturnix coturnix japonica

Abstract

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