Calcium channel blockade: Possible explanation for thioridazine's peripheral side effects

R. J. Gould, K. M.M. Murphy, I. J. Reynolds, S. H. Snyder

Research output: Contribution to journalArticle

Abstract

The authors show that thioridazine possesses calcium antagonist activity which may relate to its cardiac and sexual side effects. Binding sites associated with voltage-operated calcium channels were labeled by 3H-nitrendipine. Thioridazine influenced this binding of 3H-nitrendipine in a fashion similar to known calcium antagonists such as verapamil. Thioridazine also antagonized potassium-induced, calcium-dependent contractions of rat vas deferens, with similar potency. Thioridazine concentrations that exert calcium channel antagonist effect correspond to blood levels at therapeutic doses.

Original languageEnglish (US)
Pages (from-to)352-357
Number of pages6
JournalAmerican Journal of Psychiatry
Volume141
Issue number3
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Psychiatry and Mental health

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