Calcium channel blockade: Possible explanation for thioridazine's peripheral side effects

R. J. Gould, K. M M Murphy, I. J. Reynolds, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

The authors show that thioridazine possesses calcium antagonist activity which may relate to its cardiac and sexual side effects. Binding sites associated with voltage-operated calcium channels were labeled by 3H-nitrendipine. Thioridazine influenced this binding of 3H-nitrendipine in a fashion similar to known calcium antagonists such as verapamil. Thioridazine also antagonized potassium-induced, calcium-dependent contractions of rat vas deferens, with similar potency. Thioridazine concentrations that exert calcium channel antagonist effect correspond to blood levels at therapeutic doses.

Original languageEnglish (US)
Pages (from-to)352-357
Number of pages6
JournalAmerican Journal of Psychiatry
Volume141
Issue number3
StatePublished - 1984

Fingerprint

Thioridazine
Calcium Channels
Nitrendipine
Calcium
Vas Deferens
Calcium Channel Blockers
Verapamil
Potassium
Binding Sites

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Calcium channel blockade : Possible explanation for thioridazine's peripheral side effects. / Gould, R. J.; Murphy, K. M M; Reynolds, I. J.; Snyder, Solomon H.

In: American Journal of Psychiatry, Vol. 141, No. 3, 1984, p. 352-357.

Research output: Contribution to journalArticle

Gould, R. J. ; Murphy, K. M M ; Reynolds, I. J. ; Snyder, Solomon H. / Calcium channel blockade : Possible explanation for thioridazine's peripheral side effects. In: American Journal of Psychiatry. 1984 ; Vol. 141, No. 3. pp. 352-357.
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