Calcium attenuates epinephrine's β-adrenergic effects in postoperative heart surgery patients

Gary P. Zaloga, Robert A. Strickland, John F. Butterworth IV, Lynette J Mark, Stephen A. Mills, C. Raymond Lake

Research output: Contribution to journalArticle

Abstract

Epinephrine and calcium possess both cardiac inotropic and vasopressor activity. In addition, epinephrine's cardiovascular effects are mediated via increases in intracellular calcium. As a result, many clinicians administer the two agents together in an attempt to augment their effects. Although this approach seems rational, it has never been proven effective. We evaluated the cardiovascular and hyperglycemic actions of epinephrine (10 and 30 ng/kg/min), with and without calcium chloride administration (10 mg/kg bolus followed by 2 mg/kg/hr infusion), in a prospective, randomized, blinded, crossover designed study. Twelve adult patients were studied 1 day after aortocoronary bypass surgery. Calcium chloride raised ionized calcium levels from 1.06±0.03 (mean±SEM) to 1.44±0.05 mM (p2. After calcium, epinephrine failed to significantly increase cardiac index. Epinephrine at 30 ng/kg/min significantly increased mean arterial pressure from 87±1 to 95±2 mm Hg (p

Original languageEnglish (US)
Pages (from-to)196-200
Number of pages5
JournalCirculation
Volume81
Issue number1
StatePublished - Jan 1990
Externally publishedYes

Fingerprint

Adrenergic Agents
Epinephrine
Thoracic Surgery
Calcium
Calcium Chloride
Coronary Artery Bypass
Cross-Over Studies
Arterial Pressure

Keywords

  • Calcium
  • Cardiac output
  • Catecholamines
  • Epinephrine
  • Inotropic agents
  • Surgery, heart

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Zaloga, G. P., Strickland, R. A., Butterworth IV, J. F., Mark, L. J., Mills, S. A., & Lake, C. R. (1990). Calcium attenuates epinephrine's β-adrenergic effects in postoperative heart surgery patients. Circulation, 81(1), 196-200.

Calcium attenuates epinephrine's β-adrenergic effects in postoperative heart surgery patients. / Zaloga, Gary P.; Strickland, Robert A.; Butterworth IV, John F.; Mark, Lynette J; Mills, Stephen A.; Lake, C. Raymond.

In: Circulation, Vol. 81, No. 1, 01.1990, p. 196-200.

Research output: Contribution to journalArticle

Zaloga, GP, Strickland, RA, Butterworth IV, JF, Mark, LJ, Mills, SA & Lake, CR 1990, 'Calcium attenuates epinephrine's β-adrenergic effects in postoperative heart surgery patients', Circulation, vol. 81, no. 1, pp. 196-200.
Zaloga GP, Strickland RA, Butterworth IV JF, Mark LJ, Mills SA, Lake CR. Calcium attenuates epinephrine's β-adrenergic effects in postoperative heart surgery patients. Circulation. 1990 Jan;81(1):196-200.
Zaloga, Gary P. ; Strickland, Robert A. ; Butterworth IV, John F. ; Mark, Lynette J ; Mills, Stephen A. ; Lake, C. Raymond. / Calcium attenuates epinephrine's β-adrenergic effects in postoperative heart surgery patients. In: Circulation. 1990 ; Vol. 81, No. 1. pp. 196-200.
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