Calcium-atpase activity in cystic fibrosis erythrocyte membranes: Decreased activity in patients with pancreatic insufficiency

Dorr G. Dearborn, Robert J. Wityk, Lynelle R. Johnson, Louis Poncz, Robert C. Stern

Research output: Contribution to journalArticle

Abstract

The activity of Ca-ATPase (Ca2+, Mg2+-ATPase, ATP phosphohydrolase, EC 3.6.1.3) was measured in erythrocyte membrane preparations from 37 cystic fibrosis patients, 27 with pancreatic insufficiency and 10 with pancreatic sufficiency, from 24 healthy controls. The mean maximal calcium-stimulated specific activities, in the absence and presence of purified calmodulin, of the pancreatic sufficient patients (34.3 ± 4.2 and 75.9 ± 6.9 nmol/min/mg) was indistinguishable from that of controls (35.8 ± 2.6 and 84.3 ± 4.7 nmol/min/mg), while both activities of patients with pancreatic insufficiency were significantly decreased (28.9 ± 1.3, p

Original languageEnglish (US)
Pages (from-to)890-895
Number of pages6
JournalPediatric Research
Volume18
Issue number9
StatePublished - 1984
Externally publishedYes

Fingerprint

Exocrine Pancreatic Insufficiency
Calcium-Transporting ATPases
Erythrocyte Membrane
Cystic Fibrosis
Ca(2+) Mg(2+)-ATPase
Calmodulin
Adenosine Triphosphatases
Calcium

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Dearborn, D. G., Wityk, R. J., Johnson, L. R., Poncz, L., & Stern, R. C. (1984). Calcium-atpase activity in cystic fibrosis erythrocyte membranes: Decreased activity in patients with pancreatic insufficiency. Pediatric Research, 18(9), 890-895.

Calcium-atpase activity in cystic fibrosis erythrocyte membranes : Decreased activity in patients with pancreatic insufficiency. / Dearborn, Dorr G.; Wityk, Robert J.; Johnson, Lynelle R.; Poncz, Louis; Stern, Robert C.

In: Pediatric Research, Vol. 18, No. 9, 1984, p. 890-895.

Research output: Contribution to journalArticle

Dearborn, DG, Wityk, RJ, Johnson, LR, Poncz, L & Stern, RC 1984, 'Calcium-atpase activity in cystic fibrosis erythrocyte membranes: Decreased activity in patients with pancreatic insufficiency', Pediatric Research, vol. 18, no. 9, pp. 890-895.
Dearborn, Dorr G. ; Wityk, Robert J. ; Johnson, Lynelle R. ; Poncz, Louis ; Stern, Robert C. / Calcium-atpase activity in cystic fibrosis erythrocyte membranes : Decreased activity in patients with pancreatic insufficiency. In: Pediatric Research. 1984 ; Vol. 18, No. 9. pp. 890-895.
@article{2e2dae73516b41bc9039f71d98955b9a,
title = "Calcium-atpase activity in cystic fibrosis erythrocyte membranes: Decreased activity in patients with pancreatic insufficiency",
abstract = "The activity of Ca-ATPase (Ca2+, Mg2+-ATPase, ATP phosphohydrolase, EC 3.6.1.3) was measured in erythrocyte membrane preparations from 37 cystic fibrosis patients, 27 with pancreatic insufficiency and 10 with pancreatic sufficiency, from 24 healthy controls. The mean maximal calcium-stimulated specific activities, in the absence and presence of purified calmodulin, of the pancreatic sufficient patients (34.3 ± 4.2 and 75.9 ± 6.9 nmol/min/mg) was indistinguishable from that of controls (35.8 ± 2.6 and 84.3 ± 4.7 nmol/min/mg), while both activities of patients with pancreatic insufficiency were significantly decreased (28.9 ± 1.3, p",
author = "Dearborn, {Dorr G.} and Wityk, {Robert J.} and Johnson, {Lynelle R.} and Louis Poncz and Stern, {Robert C.}",
year = "1984",
language = "English (US)",
volume = "18",
pages = "890--895",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Calcium-atpase activity in cystic fibrosis erythrocyte membranes

T2 - Decreased activity in patients with pancreatic insufficiency

AU - Dearborn, Dorr G.

AU - Wityk, Robert J.

AU - Johnson, Lynelle R.

AU - Poncz, Louis

AU - Stern, Robert C.

PY - 1984

Y1 - 1984

N2 - The activity of Ca-ATPase (Ca2+, Mg2+-ATPase, ATP phosphohydrolase, EC 3.6.1.3) was measured in erythrocyte membrane preparations from 37 cystic fibrosis patients, 27 with pancreatic insufficiency and 10 with pancreatic sufficiency, from 24 healthy controls. The mean maximal calcium-stimulated specific activities, in the absence and presence of purified calmodulin, of the pancreatic sufficient patients (34.3 ± 4.2 and 75.9 ± 6.9 nmol/min/mg) was indistinguishable from that of controls (35.8 ± 2.6 and 84.3 ± 4.7 nmol/min/mg), while both activities of patients with pancreatic insufficiency were significantly decreased (28.9 ± 1.3, p

AB - The activity of Ca-ATPase (Ca2+, Mg2+-ATPase, ATP phosphohydrolase, EC 3.6.1.3) was measured in erythrocyte membrane preparations from 37 cystic fibrosis patients, 27 with pancreatic insufficiency and 10 with pancreatic sufficiency, from 24 healthy controls. The mean maximal calcium-stimulated specific activities, in the absence and presence of purified calmodulin, of the pancreatic sufficient patients (34.3 ± 4.2 and 75.9 ± 6.9 nmol/min/mg) was indistinguishable from that of controls (35.8 ± 2.6 and 84.3 ± 4.7 nmol/min/mg), while both activities of patients with pancreatic insufficiency were significantly decreased (28.9 ± 1.3, p

UR - http://www.scopus.com/inward/record.url?scp=0021249182&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021249182&partnerID=8YFLogxK

M3 - Article

C2 - 6091022

AN - SCOPUS:0021249182

VL - 18

SP - 890

EP - 895

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 9

ER -