Calcium-Antagonist Receptors in Cardiomyopathy

Martin J. Lohse, Harlan F. Weisman, Frederic L. Sax, John A. Wagner, James Porterfield, Charles L. Mcintosh, Myron L. Weisfeldt, Solomon H. Snyder, Stephen E. Epstein

Research output: Contribution to journalLetter


To the Editor: Wagner et al. (March 23 issue)1 provide evidence for an association of hypertrophic cardiomyopathy with an increased density of voltage-sensitive calcium channels in the heart. The mean (±SD) number of channels in atrial tissue, as assessed by binding of a calcium antagonist, was 299±108 fmol per milligram of protein in patients with other cardiac disorders and 397 ±104 fmol per milligram of protein in patients with hypertrophic cardiomyopathy. However, the authors may have overlooked an additional factor determining the number of binding sites for calcium antagonists: previous treatment with these drugs. In the group of patients with.

Original languageEnglish (US)
Pages (from-to)686-687
Number of pages2
JournalNew England Journal of Medicine
Issue number10
StatePublished - Sep 7 1989


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lohse, M. J., Weisman, H. F., Sax, F. L., Wagner, J. A., Porterfield, J., Mcintosh, C. L., Weisfeldt, M. L., Snyder, S. H., & Epstein, S. E. (1989). Calcium-Antagonist Receptors in Cardiomyopathy. New England Journal of Medicine, 321(10), 686-687.