To the Editor: Wagner et al. (March 23 issue)1 provide evidence for an association of hypertrophic cardiomyopathy with an increased density of voltage-sensitive calcium channels in the heart. The mean (±SD) number of channels in atrial tissue, as assessed by binding of a calcium antagonist, was 299±108 fmol per milligram of protein in patients with other cardiac disorders and 397 ±104 fmol per milligram of protein in patients with hypertrophic cardiomyopathy. However, the authors may have overlooked an additional factor determining the number of binding sites for calcium antagonists: previous treatment with these drugs. In the group of patients with.
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