Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial

Erin S. LeBlanc, Haley Hedlin, Feifei Qin, Manisha Desai, Jean Wactawski-Wende, Nancy Perrin, Joann E. Manson, Karen C. Johnson, Kamal Masaki, Frances A. Tylavsky, Marcia L. Stefanick

Research output: Contribution to journalArticlepeer-review

Abstract

Background: It is unknown whether supplementation with calcium and vitamin D has an impact on menopause-related symptoms. Methods: As part of the Women's Health Initiative Calcium/Vitamin D Supplementation Trial (CaD), women were randomized at 40 clinical sites to elemental calcium carbonate 1000 mg with vitamin D 400 IU daily or placebo. At the CaD baseline visit (year 1 or year 2) and during a mean follow-up of 5.7 years, participants provided data on menopause-related symptoms via questionnaires. Generalized linear mixed effects techniques were used to address research questions. Results: After excluding participants with missing data (N = 2125), we compared menopause-related symptoms at follow-up visits of 17,101 women randomized to CaD with those of 17,056 women given the placebo. Women in the CaD arm did not have a different number of symptoms at follow-up compared to women taking the placebo (p = 0.702). Similarly, there was no difference between sleep disturbance, emotional well-being, or energy/fatigue at follow-up in those who were randomized to CaD supplementation compared to those taking the placebo. Conclusions: Our data suggest that supplementation with 1000 mg of calcium plus 400 IU of vitamin D does not influence menopause-related symptoms over an average of 5.7 years of follow-up among postmenopausal women with an average age of 64 at the WHI baseline visit.

Original languageEnglish (US)
Pages (from-to)377-383
Number of pages7
JournalMaturitas
Volume81
Issue number3
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Keywords

  • Calcium
  • Hot flashes
  • Menopause
  • Mood
  • Sleep
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynecology

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