Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells

Medicine & Life Sciences

• Staurosporine 100%
• PC12 Cells 93%
• Reactive Oxygen Species 65%
• Calcium 56%
• Apoptosis 50%
• Calcium Chelating Agents 16%
• 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 16%
• bcl-2 Genes 15%
• Peroxynitrous Acid 14%
• Caspase Inhibitors 14%
• thiazolyl blue 14%
• Membrane Lipids 13%
• Alkaloids 12%
• Nerve Growth Factor 12%
• Mitochondrial Membrane Potential 12%
• Uric Acid 11%
• Caspases 11%
• Cultured Cells 9%
• Cell Death 8%
• Oxidative Stress 8%
• Neurons 7%
• Serum 5%