Calcium and its role in myocardial cell injury during ischemia and reperfusion

E. Marban, Y. Koretsune, M. Corretti, V. P. Chacko, H. Kusuoka

Research output: Contribution to journalArticlepeer-review

140 Scopus citations


Direct measurements of intracellular free Ca2+ concentration ([Ca2+](i)) were obtained during ischemia and reperfusion in ferret hearts loaded with the Ca2+ indicator, the 5,5'-difluoro derivative of 1,2-bis(o-aminophenoxy)ethane-N,N,N',N',-tetraacetic acid. During 15 minutes of ischemia at 37°C, time-averaged [Ca2+](i) increased significantly and rapidly during reperfusion. In contrast to metabolic inhibition in isolated muscle or cells, the increase in [Ca2+](i) during true ischemia occurs in the absence of a mechanical contracture. After ischemia, contractile function does not recover completely: the hearts are 'stunned'. Our results support the hypothesis that an increase in cellular calcium-loading causes dysfunction in the form of myocardial stunning while leaving unresolved the precise mechanism of the calcium-mediated injury.

Original languageEnglish (US)
Pages (from-to)IV-17-IV-22
Issue number6 SUPPL.
StatePublished - Dec 1 1989

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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