Calcium absorption is significantly higher in adolescents during pregnancy than in the early postpartum period

Kimberly O. O'Brien, Maureen Schulman Nathanson, Jeri Mancini, Frank R Witter

Research output: Contribution to journalArticle

Abstract

Background: Early childbearing may limit skeletal consolidation and increase calcium demands in adolescents. Objective: The purpose of this study was to characterize calcium absorption in pregnant and lactating adolescents. Design: Fractional calcium absorption was evaluated in 23 adolescents (mean ± SD age: 16.5 ± 1.4 y) during the third trimester of pregnancy (34.7 ± 1.0 wk gestation) and again in 15 of these adolescents 31 ± 8 d after delivery. Eight adolescents were breastfeeding their infants during the follow-up study. Fractional calcium absorption was determined by using oral (46Ca or 44Ca) and intravenous ( 42Ca) stable calcium isotopes. Total-body and lumbar spine bone mineral density were measured in adolescents during the postpartum period by using dual-energy X-ray absorptiometry. Results: Fractional calcium absorption was significantly greater during pregnancy than at 3-4 wk postpartum [0.526 ± 0.152 (n = 23) compared with 0.297 ± 0.108 (n = 15); P <0.0001]. Lumbar spine z scores measured 19-44 d after delivery (n = 15) were significantly associated with calcium intake during pregnancy (y = -3.53 + 0.107x; R2 = 0.355, P <0.02) and were inversely related to fractional calcium absorption during pregnancy (y = 3.489 - 6.66x; R2 = 0.52, P = 0.002). A total of 33% (5/15) of adolescents had lumbar spine z scores that met the definition of osteopenia (n = 3) or osteoporosis (n = 2) in the early postpartum period. Conclusions: Calcium absorption in adolescents was significantly higher during the third trimester of pregnancy than in the early postpartum period, and higher calcium intakes during pregnancy appeared to be protective against loss of trabecular bone at the lumbar spine.

Original languageEnglish (US)
Pages (from-to)1188-1193
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume78
Issue number6
StatePublished - Dec 2003

Fingerprint

pregnant adolescents
Pregnancy in Adolescence
postpartum period
Postpartum Period
Calcium
calcium
lumbar spine
pregnancy
Spine
Pregnancy
Third Pregnancy Trimester
Calcium Isotopes
osteopenia
Metabolic Bone Diseases
Photon Absorptiometry
dual-energy X-ray absorptiometry
Breast Feeding
osteoporosis
breast feeding
bone density

Keywords

  • Adolescents
  • Bone
  • Calcium absorption
  • Lactation
  • Pregnancy
  • Stable isotopes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Calcium absorption is significantly higher in adolescents during pregnancy than in the early postpartum period. / O'Brien, Kimberly O.; Nathanson, Maureen Schulman; Mancini, Jeri; Witter, Frank R.

In: American Journal of Clinical Nutrition, Vol. 78, No. 6, 12.2003, p. 1188-1193.

Research output: Contribution to journalArticle

O'Brien, Kimberly O. ; Nathanson, Maureen Schulman ; Mancini, Jeri ; Witter, Frank R. / Calcium absorption is significantly higher in adolescents during pregnancy than in the early postpartum period. In: American Journal of Clinical Nutrition. 2003 ; Vol. 78, No. 6. pp. 1188-1193.
@article{e62896bb90c24eec9c7fcd47f47c4812,
title = "Calcium absorption is significantly higher in adolescents during pregnancy than in the early postpartum period",
abstract = "Background: Early childbearing may limit skeletal consolidation and increase calcium demands in adolescents. Objective: The purpose of this study was to characterize calcium absorption in pregnant and lactating adolescents. Design: Fractional calcium absorption was evaluated in 23 adolescents (mean ± SD age: 16.5 ± 1.4 y) during the third trimester of pregnancy (34.7 ± 1.0 wk gestation) and again in 15 of these adolescents 31 ± 8 d after delivery. Eight adolescents were breastfeeding their infants during the follow-up study. Fractional calcium absorption was determined by using oral (46Ca or 44Ca) and intravenous ( 42Ca) stable calcium isotopes. Total-body and lumbar spine bone mineral density were measured in adolescents during the postpartum period by using dual-energy X-ray absorptiometry. Results: Fractional calcium absorption was significantly greater during pregnancy than at 3-4 wk postpartum [0.526 ± 0.152 (n = 23) compared with 0.297 ± 0.108 (n = 15); P <0.0001]. Lumbar spine z scores measured 19-44 d after delivery (n = 15) were significantly associated with calcium intake during pregnancy (y = -3.53 + 0.107x; R2 = 0.355, P <0.02) and were inversely related to fractional calcium absorption during pregnancy (y = 3.489 - 6.66x; R2 = 0.52, P = 0.002). A total of 33{\%} (5/15) of adolescents had lumbar spine z scores that met the definition of osteopenia (n = 3) or osteoporosis (n = 2) in the early postpartum period. Conclusions: Calcium absorption in adolescents was significantly higher during the third trimester of pregnancy than in the early postpartum period, and higher calcium intakes during pregnancy appeared to be protective against loss of trabecular bone at the lumbar spine.",
keywords = "Adolescents, Bone, Calcium absorption, Lactation, Pregnancy, Stable isotopes",
author = "O'Brien, {Kimberly O.} and Nathanson, {Maureen Schulman} and Jeri Mancini and Witter, {Frank R}",
year = "2003",
month = "12",
language = "English (US)",
volume = "78",
pages = "1188--1193",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "6",

}

TY - JOUR

T1 - Calcium absorption is significantly higher in adolescents during pregnancy than in the early postpartum period

AU - O'Brien, Kimberly O.

AU - Nathanson, Maureen Schulman

AU - Mancini, Jeri

AU - Witter, Frank R

PY - 2003/12

Y1 - 2003/12

N2 - Background: Early childbearing may limit skeletal consolidation and increase calcium demands in adolescents. Objective: The purpose of this study was to characterize calcium absorption in pregnant and lactating adolescents. Design: Fractional calcium absorption was evaluated in 23 adolescents (mean ± SD age: 16.5 ± 1.4 y) during the third trimester of pregnancy (34.7 ± 1.0 wk gestation) and again in 15 of these adolescents 31 ± 8 d after delivery. Eight adolescents were breastfeeding their infants during the follow-up study. Fractional calcium absorption was determined by using oral (46Ca or 44Ca) and intravenous ( 42Ca) stable calcium isotopes. Total-body and lumbar spine bone mineral density were measured in adolescents during the postpartum period by using dual-energy X-ray absorptiometry. Results: Fractional calcium absorption was significantly greater during pregnancy than at 3-4 wk postpartum [0.526 ± 0.152 (n = 23) compared with 0.297 ± 0.108 (n = 15); P <0.0001]. Lumbar spine z scores measured 19-44 d after delivery (n = 15) were significantly associated with calcium intake during pregnancy (y = -3.53 + 0.107x; R2 = 0.355, P <0.02) and were inversely related to fractional calcium absorption during pregnancy (y = 3.489 - 6.66x; R2 = 0.52, P = 0.002). A total of 33% (5/15) of adolescents had lumbar spine z scores that met the definition of osteopenia (n = 3) or osteoporosis (n = 2) in the early postpartum period. Conclusions: Calcium absorption in adolescents was significantly higher during the third trimester of pregnancy than in the early postpartum period, and higher calcium intakes during pregnancy appeared to be protective against loss of trabecular bone at the lumbar spine.

AB - Background: Early childbearing may limit skeletal consolidation and increase calcium demands in adolescents. Objective: The purpose of this study was to characterize calcium absorption in pregnant and lactating adolescents. Design: Fractional calcium absorption was evaluated in 23 adolescents (mean ± SD age: 16.5 ± 1.4 y) during the third trimester of pregnancy (34.7 ± 1.0 wk gestation) and again in 15 of these adolescents 31 ± 8 d after delivery. Eight adolescents were breastfeeding their infants during the follow-up study. Fractional calcium absorption was determined by using oral (46Ca or 44Ca) and intravenous ( 42Ca) stable calcium isotopes. Total-body and lumbar spine bone mineral density were measured in adolescents during the postpartum period by using dual-energy X-ray absorptiometry. Results: Fractional calcium absorption was significantly greater during pregnancy than at 3-4 wk postpartum [0.526 ± 0.152 (n = 23) compared with 0.297 ± 0.108 (n = 15); P <0.0001]. Lumbar spine z scores measured 19-44 d after delivery (n = 15) were significantly associated with calcium intake during pregnancy (y = -3.53 + 0.107x; R2 = 0.355, P <0.02) and were inversely related to fractional calcium absorption during pregnancy (y = 3.489 - 6.66x; R2 = 0.52, P = 0.002). A total of 33% (5/15) of adolescents had lumbar spine z scores that met the definition of osteopenia (n = 3) or osteoporosis (n = 2) in the early postpartum period. Conclusions: Calcium absorption in adolescents was significantly higher during the third trimester of pregnancy than in the early postpartum period, and higher calcium intakes during pregnancy appeared to be protective against loss of trabecular bone at the lumbar spine.

KW - Adolescents

KW - Bone

KW - Calcium absorption

KW - Lactation

KW - Pregnancy

KW - Stable isotopes

UR - http://www.scopus.com/inward/record.url?scp=0642337756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0642337756&partnerID=8YFLogxK

M3 - Article

C2 - 14668282

AN - SCOPUS:0642337756

VL - 78

SP - 1188

EP - 1193

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 6

ER -