Calcitonin therapy of children with osteogenesis imperfecta

Gilbert P. August, Jay Shapiro, Wellington Hung

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Two children, ages 13 2/12 and 2 6/12 years, with osteogenesis imperfecta were treated with salmon calcitonin. During the course of therapy the older child developed calcitonin dose-related hypomagnesemia on two occasions. The younger child, coincident with otitis media and vomiting, developed hypomagnesemia, hypophosphatemia, hyponatremia, and hypokalemia. Since rib biopsies obtained before and after one year of treatment with salmon calcitonin failed to demonstrate any histologic changes, therapy was discontinued because of the induced metabolic consequences of calcitonin therapy.

Original languageEnglish (US)
Pages (from-to)1001-1005
Number of pages5
JournalThe Journal of pediatrics
Issue number6
StatePublished - Dec 1977
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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