TY - JOUR
T1 - Calcitonin therapy of children with osteogenesis imperfecta
AU - August, Gilbert P.
AU - Shapiro, Jay
AU - Hung, Wellington
N1 - Funding Information:
From the Department of Endocrinology and Metabolism of the Children's Hospital National Medical Center, the Greater Southeast Community Medical Center, and the Department of Child Health of the George Washington University School of Medicine. Supported by General Research Support Grant RR-005515 and General Clinical Research Center Grant RR-00284, National Institutes of Health. *Reprint address: Children's Hospital National Medical Center, 2125 13th St., N. I'K, Washington, DIC. 20009.
PY - 1977/12
Y1 - 1977/12
N2 - Two children, ages 13 2/12 and 2 6/12 years, with osteogenesis imperfecta were treated with salmon calcitonin. During the course of therapy the older child developed calcitonin dose-related hypomagnesemia on two occasions. The younger child, coincident with otitis media and vomiting, developed hypomagnesemia, hypophosphatemia, hyponatremia, and hypokalemia. Since rib biopsies obtained before and after one year of treatment with salmon calcitonin failed to demonstrate any histologic changes, therapy was discontinued because of the induced metabolic consequences of calcitonin therapy.
AB - Two children, ages 13 2/12 and 2 6/12 years, with osteogenesis imperfecta were treated with salmon calcitonin. During the course of therapy the older child developed calcitonin dose-related hypomagnesemia on two occasions. The younger child, coincident with otitis media and vomiting, developed hypomagnesemia, hypophosphatemia, hyponatremia, and hypokalemia. Since rib biopsies obtained before and after one year of treatment with salmon calcitonin failed to demonstrate any histologic changes, therapy was discontinued because of the induced metabolic consequences of calcitonin therapy.
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U2 - 10.1016/S0022-3476(77)80916-5
DO - 10.1016/S0022-3476(77)80916-5
M3 - Article
C2 - 562930
AN - SCOPUS:0017662644
VL - 91
SP - 1001
EP - 1005
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 6
ER -