Calcitonin therapy of children with osteogenesis imperfecta

Gilbert P. August, Jay Shapiro, Wellington Hung

Research output: Contribution to journalArticle

Abstract

Two children, ages 13 2/12 and 2 6/12 years, with osteogenesis imperfecta were treated with salmon calcitonin. During the course of therapy the older child developed calcitonin dose-related hypomagnesemia on two occasions. The younger child, coincident with otitis media and vomiting, developed hypomagnesemia, hypophosphatemia, hyponatremia, and hypokalemia. Since rib biopsies obtained before and after one year of treatment with salmon calcitonin failed to demonstrate any histologic changes, therapy was discontinued because of the induced metabolic consequences of calcitonin therapy.

Original languageEnglish (US)
Pages (from-to)1001-1005
Number of pages5
JournalJournal of Pediatrics
Volume91
Issue number6
DOIs
StatePublished - 1977
Externally publishedYes

Fingerprint

Osteogenesis Imperfecta
salmon calcitonin
Calcitonin
Hypophosphatemia
Hypokalemia
Hyponatremia
Otitis Media
Ribs
Therapeutics
Vomiting
Biopsy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Calcitonin therapy of children with osteogenesis imperfecta. / August, Gilbert P.; Shapiro, Jay; Hung, Wellington.

In: Journal of Pediatrics, Vol. 91, No. 6, 1977, p. 1001-1005.

Research output: Contribution to journalArticle

August, Gilbert P. ; Shapiro, Jay ; Hung, Wellington. / Calcitonin therapy of children with osteogenesis imperfecta. In: Journal of Pediatrics. 1977 ; Vol. 91, No. 6. pp. 1001-1005.
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