Caffeinated Coffee Consumption, Cardiovascular Disease, and Heart Valve Disease in the Elderly (from the Framingham Study)

James A. Greenberg, Grant Chow, Roy Ziegelstein

Research output: Contribution to journalArticle


The relation between caffeinated coffee consumption and heart disease morbidity and mortality is of great interest given the extensive use of this beverage. A recent prospective epidemiologic study found a strong protective association in elderly subjects without moderate to severe hypertension in the NHANES. To test this association in the Framingham Heart Study population, in which cardiovascular risk factors and health behaviors were carefully documented, Cox regression analyses were conducted for 1,354 subjects aged 65.4 to 96.6 years at study entry. There were 210 deaths from cardiovascular disease and 118 from coronary heart disease (CHD) during 10.1 years of follow-up. A significant negative association between caffeinated coffee consumption and CHD mortality was observed for subjects with systolic blood pressure (BP)

Original languageEnglish (US)
Pages (from-to)1502-1508
Number of pages7
JournalThe American Journal of Cardiology
Issue number11
Publication statusPublished - Dec 1 2008


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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